嚴重阻塞性睡眠呼吸中止症患者其呼吸道發炎反應與肺功能之探討

Investigation of Airway Inflammation and Pulmonary Function in Patients with Severe Obstructive Sleep Apnea

林珮君(Pei-Chun Lin) ； 李佩玲(Pei-Lin Lee) ； 吳惠東(Hui-Dung Wu) ； 莊雅惠(Ya-Hui Chuang) ； 王儷穎(Li-Ying Wang)

《物理治療》 35卷1期 (2010/03) Pp. 16-23

摘要

Background and Purpose: Obstructive sleep apnea (OSA) is characterized by episodes of repetitive upper airway obstruction during sleep. Evidence of both systemic and airway inflammation had been found in patients with OSA. However, the relationship between airway inflammation and pulmonary function remains unclear. The objective of this study were (1) to evaluate the degree of airway inflammation by induced sputum in patients with severe OSA, and (2) to investigate the correlations between airway inflammation, disease severity, and pulmonary function parameters. Methods: Twenty treatment-naïve patients with severe OSA (mean age: 50.35±8.95 y/o) were recruited. Spirometry was used to evaluate pulmonary function and airway inflammation was assessed by induced sputum. Pearson correlation coefficient was used to explore the correlations between parameters. Results: The mean FVC (102.72±11.10% of predicted) and FEy1 (97.78±12.03% of predicted) of all subjects were within normal range, and the mean FEV1/FVC ratio was 77.20±3.43%. Compared to healthy population, the FEF(subscript 25-75) was relatively low in patients with severe OSA (68.70±14.40% of predicted). The mean cell concentration in induced sputum was 2.01±1.37×10^6 cells/ml. The neutrophil and macrophage percentage in induced sputum was 59.20±20.94% and 30.04±20.67%, respectively. Significant positive correlation between AHI and neutrophil percentage was found (r=0.45, p＜0.05), and AHI was negatively correlated with macrophage percentage (r=-0.45. p＜0.05). No significant correlation was found between inflammatory markers and pulmonary function parameters in the study population. Conclusions: Airway inflammation existed in patients with severe OSA, which was characterized by a higher neutrophil and a lower macrophage percentage. Disease severity was found to moderately correlate with airway inflammation. Lower FEF(subscript 25-75) predicted value suggested that it is necessary to evaluate the small airway function of these patients longitudinally.

關鍵字

阻塞性睡眠呼吸中止症 ； 發炎反應 ； 肺功能

並列摘要

Background and Purpose: Obstructive sleep apnea (OSA) is characterized by episodes of repetitive upper airway obstruction during sleep. Evidence of both systemic and airway inflammation had been found in patients with OSA. However, the relationship between airway inflammation and pulmonary function remains unclear. The objective of this study were (1) to evaluate the degree of airway inflammation by induced sputum in patients with severe OSA, and (2) to investigate the correlations between airway inflammation, disease severity, and pulmonary function parameters. Methods: Twenty treatment-naïve patients with severe OSA (mean age: 50.35±8.95 y/o) were recruited. Spirometry was used to evaluate pulmonary function and airway inflammation was assessed by induced sputum. Pearson correlation coefficient was used to explore the correlations between parameters. Results: The mean FVC (102.72±11.10% of predicted) and FEy1 (97.78±12.03% of predicted) of all subjects were within normal range, and the mean FEV1/FVC ratio was 77.20±3.43%. Compared to healthy population, the FEF(subscript 25-75) was relatively low in patients with severe OSA (68.70±14.40% of predicted). The mean cell concentration in induced sputum was 2.01±1.37×10^6 cells/ml. The neutrophil and macrophage percentage in induced sputum was 59.20±20.94% and 30.04±20.67%, respectively. Significant positive correlation between AHI and neutrophil percentage was found (r=0.45, p＜0.05), and AHI was negatively correlated with macrophage percentage (r=-0.45. p＜0.05). No significant correlation was found between inflammatory markers and pulmonary function parameters in the study population. Conclusions: Airway inflammation existed in patients with severe OSA, which was characterized by a higher neutrophil and a lower macrophage percentage. Disease severity was found to moderately correlate with airway inflammation. Lower FEF(subscript 25-75) predicted value suggested that it is necessary to evaluate the small airway function of these patients longitudinally.

並列關鍵字

Obstructive sleep apnea ； Inflammation ； Pulmonary function