Purpose. Fournier's gangrene is predominantly a disease of males. The present study reviews our 10-year experience with Fournier's gangrene in female patients. Methods. A retrospective review of 8 consecutive female patients with Fournier's gangrene was performed. Demographic characteristics, bacteriology study, and treatment results were recorded. Results. Mean age was 74.3 years (range, 54-96 years). Most cases of Fournier's gangrene originated from anorectal infections. Diabetes was the most common comorbid condition. Polymicrobial infection occurred in most patients. No predominant organism was found. Half of the patients had infection extending beyond the perianal and perineal regions. Seven (87.5%) patients received fecal diversion. The mortality rate was 25%. Conclusions. Fournier's gangrene occurred in females with a pattern similar to that in males. However, most female patients received fecal diversion.