Objective: Most patients with cleft lip and palate have problems with eating and speech. Obturator is a prosthesis designed to close up the defected palate to aid speech, mastication, esthetics, and proper air flow. Previous studies have suggested that selection of proper material and tray are crucial to obtain optimal treatment outcome for patients with cleft lip and palate. We reported a 46 year-old male patient with cleft palate accompanied with multiple dental complications and the procedures to restore his speech and mastication function with a complete denture in combination of an obturator. With a sequential rehabilitation protocol including the surgical reduction of posterior flanges to lessen gag reflex reaction, his symptoms were relieved and the treatment outcome was satisfactory.