Coleridgean scholarship in the past decade has marked the significance of disease metaphors in ”The Rime of the Ancient Mariner,” ascribing them to the ills of British imperial expansionism in the Romantic colonization. Rod Edmond further brings together leprosy and the anti-slavery discourse. However, the latter is nowhere explicit in the narrative itself whereas the consistently maintained metaphors of leprosy still continue unattended. The current study departs from Edmond's association between leprosy and slavery and proceeds to explore the allegorical Life-in-Death which substantially bears the Western cultural and Christian mystery of leprosy and crucially contributes to the functioning of divine retribution and grace at the poet's disposal. This paper attempts to explicate the mysterious incidents from both Scriptural sources of leprosy allegory and the folk beliefs which have roots in the medieval times. The poet's deployment of leprosy metaphors and its moral reflections will be duly examined.