復發性黏膜多形性紅斑－病例報告及文獻回顧

Recurrent Mucosal Erythema Multiforme-A Case Repot and Literature Review

游綉婷(Hsiu-Ting Yu) ； 郭松泊(S-B Kuo) ； 柳昭蔚(Chao-Wei Liu) ； 張陽明(Yang-Ming Chang)

《臺灣口腔顎面外科學會雜誌》 20卷4期 (2009/12) Pp. 280-287

https://doi.org/10.7104/TJOMS.200912.0280

摘要

復發性多形性紅斑是一種皮膚或黏膜的水泡性疾病，發病原因仍沒有確切的定論，但一般認爲是一種對外來抗原的過敏反應，其中最常見的誘發因子是單純疱疹的感染。口腔的病灶會導致患者進食困難，最令患者感到困擾，長期反覆的發作會逐漸耗弱患者的體力。治療方式以抗病毒acyclovir爲第一線用藥，但有時疾病非常頑強，當治療無效時，就必須作多方的嘗試，其它治療方式包括抗瘧劑、抗生素、類固醇、抗組織胺、免疫抑制劑等都有被提出報告。本文報告一起復發性黏膜多形性紅斑的病例，闡述其分類及定義的演進、臨床表徵、相關病因及現今治療方式做一文獻回顧及討論。

關鍵字

多形性紅斑 ； 復發性多形性紅斑 ； 黏膜多形性紅斑

並列摘要

Recurrent erythema multiforme is a vesiculo-bullous disease of the skin or mucous membrane. The cause of recurrent erythema multiforme is still unknown, but it often appears to be a hypersensitivity reaction to one of foreign antigens. The well-documented precipitating factors are recurrent herpes simplex viral infections. The lesions of the oral mucosa were extremely painful and many patients were unable to eat or drink and some became debilitated. Acyclovir is the first choice of treatment. However, some patients are refractory to this treatment. If this treatment is ineffective, a trial of other treatment regimens may be needed. Other treatment modalities, such as antimalarials, antibiotics, systemic corticosteroid and immunosuppressant have been reported. The purpose of this paper is to describe a case of recurrent erythema multiforme and to review the literature about its development of definition and classification, clinical manifestation, etiology and treatment methods.

並列關鍵字

erythema multiforme ； recurrent erythema multiforme ； mucosal erythema multiforme