- 期刊
- OpenAccess
A Retrospective Study to Estimate Serum Vancomycin Trough Concentrations in Pediatric Patients with Current Recommended Dosing Regimen
摘要
Vancomycin is widely prescribed to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). According to the Infectious Disease Society of America 2011 MRSA guidelines for adults, trough concentrations of 15-20 µg/ml were recommended with vancomycin 15-20 mg/kg/dose every 8-12 h not to exceed 2 g per dose in patients with normal renal function. As the data for dosage and monitoring of vancomycin in children are still controversial, physicians often follow the guidelines established for adults. To evaluate serum vancomycin trough concentrations in pediatric patients with currently recommended dosing regimen, we evaluated clinical data. Methods: This retrospective observational study collected pediatric patients aged ＜18 years for whom vancomycin was administered at a single medical center between 2009 and 2015. Results: Fifty pediatric patients were analyzed. Two groups were identified according to the vancomycin dosage. Fourteen (28%) patients underwent vancomycin at 60 mg/kg/day (high dose) and 36 (72%) patients at 40 mg/kg/day (low dose). The average serum vancomycin trough concentrations of the two groups were 13.12 µg/ml (high-dose group) and 9.02 µg/ml (low dose group), respectively. In addition, 71% (high-dose group) and 91% (low-dose group) of patients could not reach the target trough concentrations 15-20 µg/ml, set by the Infectious Disease Society of America. Conclusion: This investigation revealed that the current recommended vancomycin dosing regimens in children (40-60 mg/kg/day) mostly brought out trough concentrations ＜10 µg/ml in this research population.
延伸閱讀
- Ou, C. Y., Hsieh, K. S., Chiou, Y. H., Chang, Y. H., & Ger, L. P. (2006). A Comparative Study of Initial Use of Intravenous Immunoglobulin and Prednisolone Treatments in Childhood Idiopathic ThrombocytopenicPurpura. Acta Paediatrica Taiwanica, 47(5), 226-231. https://doi.org/10.7097/APT.200610.0226
- Tsai, J. C., Lai, Y. H., Tsai, Z. Y., Chien, L. J., & Tsai, J. H. (1991). Clinical Efficacy of Recombinant Human Erythropoietin in the Treatment of Anemia in Hemodialysis Patients: Influence of Dosing Regimen, Iron Status and Serum Aluminum. The Kaohsiung Journal of Medical Sciences, 7(3), 126-135. https://doi.org/10.6452/KJMS.199103.0126
- 游慧真（2009）。A Study of the Relationship between Suspected Enterovirus Contracted Patients’ Treatment Seeking Behavior and Treatment Outcome〔碩士論文，元智大學〕。華藝線上圖書館。https://doi.org/10.6838/YZU.2009.00108
- Ko, Y. P., Huang, C. J., Hung, Y. C., Su, N. Y., Tsai, P. S., Chen, C. C., & Cheng, C. R. (2001). Premedication with Low-dose Oral Midazolam Reduces the Incidence and Severity of Emergence Agitation in Pediatric Patients Following Sevoflurane Anesthesia. Acta Anaesthesiologica Sinica, 39(4), 169-177. https://doi.org/10.6955/AAS.200112.0169
- 路景蘭（2010）。One-year Longitudinal Follow-up of Serologic Responses to Vaccination with 7-Valent Pneumococcal Conjugate Vaccine among HIV-infected Adult Patients〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2010.00221