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Improve Urea Clearance Using Low-Flux Dialyzers in Eighteen Chronic Hemodialysis Patients - A Short Communication

摘要


The dose of hemodialysis (HD) affects survival of patients on maintenance HD, but sometimes an adequate HD dose was not achieved, despite of strategies for improving HD dose. We reported an improvement of urea reduction ratio (URR) using low-flux dialyzers in 18 chronic HD patients who were previously treated using high-flux dialyzers. METHOD: Eighteen chronic HD patients who received HD using FX100 and had a URR < 65% identified. HD using F7HPS was performed and the measurements of URR were repeated under the same HD settings. RESULTS: The HD settings used in the two measurements of URR were not different. The URR was 70 ± 3% in HD using F7HPS, significantly higher than that (62 ± 3%) in HD using FX100 (P < 0.001). The blood urea nitrogen (BUN) during HD was measured every hour in four patients and no differences in BUN removal rate in first 3 hours of HD. The major differences of BUNs were found at the 4th hour (P < 0.01). CONCLUSIONS: Inadequate dialysis dose can occur in chronic HD patients using high-flex dialyzers. We reported an improvement of urea clearance using low-flux dialyzers as such in 18 patients.

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