The Association Between Hematocrit and Triglyceride Clearance Rate in Men Receiving Double Filtration Plasmapheresis

Wei-Wen Chang ； Lin-Chien Lee ； Wei-Jie Wang ； Hung-Chieh Wu

《Acta Nephrologica》 32卷2期 (2018/06) Pp. 80-88

https://doi.org/10.6221/AN.201806_32(2).0006

摘要

BACKGROUND: Double filtration plasmapheresis (DFPP) had been known to reduce serum triglyceride (TG) values. However, several factors, including demographic and technical parameters, were associated with TG clearance rate in the modality. This study examines whether baseline hematocrit was a predictor for efficient TG removal. METHODS: Men who receiving DFPP for hyperlipidemia in Taoyuan General Hospital from January 2015 to March 2018 were classified into efficient and inefficient TG removal according to TG removal rate ≥ 50% vs. ＜ 50%. TG removal rate was defined as following formula: [(pre-apheresis TG － post-apheresis TG) / pre-apheresis TG]. Polynomial fractional analysis and best fitting curve between hematocrit and effect estimate as well as TG removal rate were calculated. Odds ratios (ORs) and 95% confidence interval (CI) were evaluated by logistic regression model including univariate and multivariate adjustment. RESULTS: From a total of 60 subjects receiving DFPP, 35 subjects reached efficient TG removal. The difference in TG removal rate and hematocrit between efficient vs. inefficient TG removal groups were 43% vs. 56% and 44.8% vs. 41.2% (Ps ＜ 0.05). After multivariate adjustment, hematocrit was a significant predictor for efficient TG removal (ORs and 95% CI were 1.167 (1.030-1.324), P ＜ 0.05). CONCLUSION: Hematocrit, a surrogate of blood viscosity, was associated with the efficiency of TG removal.

關鍵字

double filtration plasmapheresis ； triglyceride, hematocrit ； viscosity ； removal rate