Verrucous carcinoma (VC) is a well differentiated squamous cell carcinoma that is a low-grade malignancy and rarely presents with distant metastasis. According to previously reported cases, it is possible that the presence of calculi may cause chronic inflammation and traumatic irritation; this mechanism seems to promote the development of VC in the upper part of urinary tract. We present a case of verrucous carcinoma of the right renal pelvis and right ureter. Such tumors may cause severe urinary tract obstruction. Surgical treatment is the main modality of therapy. This patient received nephro-ureterectomy. Furthermore, because a microscopic residual tumor was found at the cut end of ureter, the patient also received adjuvant radiotherapy.