Current strategies of antibacterial modification on medical device surface

While medical devices are increasingly used in almost all fields of medicine for diagnosis and therapy, infections related to biomedical device arise the attention for managing the care of patients. Implant-associated infections are a major limitation in surgery and clinical applications. These infections may cause complications and result in the failure of the entire treatment. Biofilm formation on medical devices is considered as leading cause for these severe health consequences, while bacteria growing in a biofilm is tolerant to both host defense mechanisms and antibiotic therapies. For the reason, surface modification on medical implants by various physical or chemical techniques are developed to reduce the occurrence of infections related to different biomedical devices. This article provides an overview of current strategies involved in antimicrobial surface modification to prevent bacterial adhesion and biofilm inhibition on medical devices. Classifying different technologies may be useful in order to compare different solutions, and improve the design of validation tests in this rapidly rising field.

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antimicrobial surface ； medical device ； modification ； surface coating

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Current strategies of antibacterial modification on medical device surface

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