Along with the vigorous development of the digital publishing industry, researchers have found that there are significant differences in the ability of making e-books in design department. For this reason, DACUM (Developing a Curriculum) is used in this research to develop a series of "e-book production open courseware". And then use the Technology Acceptance Model (TAM) to explore the applicability of the course. The results show that perceived ease of use has significant effects on perceived usefulness, and behavioral intention is changed by the influences of user attitudes. Therefore, "e-book production open courseware" is useful for the design student's practical skills learning of e-book production to a certain extent.