Evaluation of the Feasibility of Metabolome Analyses for the Identification of Body Fluids

Yi-Ching Chen ； Yung-Fou Chen ； Hsing-Mei Hsieh ； Li-Chin Tsai

《Forensic Science Journal》 18卷1期 (2019/12) Pp. 9-18

https://doi.org/10.6593/FSJ.201912_18(1).0002

摘要

Metabolomics is regarded as a new approach for studying the composition of cells, tissues, or even the entire set of metabolic molecules in vivo after Genomics and Proteomics. Recently, there have been several papers analyzing specific metabolites in different body fluids by liquid or gas chromatography-mass spectrometry (LC-MS or GC-MS), nuclear magnetic resonance (NMR), and other ways. These diverse sets of metabolites may be potential as specific biomarkers for body fluid identification. This report summarized the research related to body fluid metabolites in published papers, and also reported the current MS and NMR papers, which were the current established analytical techniques for metabolome analyses of body fluids. Furthermore, the potential of these technologies for being applied to forensic body fluid differentiation was evaluated in this report.

關鍵字

forensic body fluid identification ； mass spectrometry ； nuclear magnetic resonance ； metabolites ； biomarkers