淺談金屬有機骨架材料在酵素固定化的應用

Metal-organic Frameworks in Enzyme Immobilization

簡琬錡(Wan-Chi Chien) ； 韋子瀚(Tz-Han Wei) ； 吳誓鴻(Shi-Hong Wu) ； 許育慎(Yu-Shen Hsu) ； 廖富祥(Fu-Siang Liao) ； 謝發坤(Fa-Kuen Shieh)

《化學》 76卷4期 (2018/12) Pp. 309-319

https://doi.org/10.6623/chem.201812_76(4).008

摘要

金屬有機骨架材料(metal-organic frameworks; MOFs)是一種新型高結晶性有機/無機複合錯合物，藉由金屬離子或是金屬團簇構成之二級構築單元(second-building unit; SBU)與多牙有機配位基透過配位共價鍵組裝而成，具備結構多樣性、可調控性、高比表面積及熱化穩定性等特點，使其不僅常應用於氣體儲存、催化、化學感測器、超級電容及藥物載體等，近年來更將其應用於酵素固定化，並以MOFs作為模板進一步探討酵素學。MOFs材料之應用不斷延伸至各個領域，其未來之潛能更是無可限量。

關鍵字

金屬有機骨架材料 ； 孔洞材料 ； 酵素固定化

並列摘要

Metal-organic frameworks (MOFs) are a porous crystalline material composed of metal nodes and organic linkers, where the physicochemical properties can be controlled through careful selection of the inorganic or organic precursors. Recently, MOFs has emerged as a novel type of crystalline porous material that combines highly desirable properties of zeolites, such as crystallinity, microporosity, high surface area, and exceptional thermal and chemical stability. Thus, MOFs show promise for a wide range of applications ranging from gas separation to biomedical science. Notably, imparting functionality to MOFs by incorporating nanoparticles, such as gold or platinum, as composites for catalysts has been viewed as a potential avenue to create fine-tuned catalytic platforms. Herein, we review the history of MOF development and MOF synthetic approaches as well as introduce its new applications in the enzyme immobilization. Therefore, MOFs materials not only have attractive prospects for the development of porous materials, but play a more important role in a wider range of fields in the future.

並列關鍵字

Metal-organic frameworks ； Porous materials ； Enzyme immobilization