以網路架構系統來視覺化果蠅神經、神經組、及神經氈結構

A Web-based System For Visualizing Drosophila Neuron Tracing, Neuron Grouping, And Neuropils

卓晉平(Chin-Ping Cho)

指導教授 ： 荊宇泰

國立交通大學/資訊學院/資訊科學與工程研究所/碩士(2018年)

摘要

In this thesis, we build a web-based system for visualizing Drosophila's neuron, neuron groups, and neuropils. This system can help neuroscieance researchers know the relation between neuron and the behavior of Drosophila more directly. The data comes from a lot of states. First, researchers use X-ray to photograph the sinogram of Drosophila's brain. Then, use the technical of image reconstruction to build the 3D volume data. Thirdly, analyze the 3D data to recognize where the neurons are and build their geometry coordination. Professor Chiang's lab in NTHU has built 27K and 16K data in the database by using neuron tracking method. Finally, these neuron data can do the grouping by analyzing the similarity between each neuron's structure. In the previous work of our lab, we have built a database that contains about 2 thousand groups. The purposes of this visualizing system are: showing these neuron data clearly and efficiently, letting researchers operate and query the data conveniently, and building a security log-in system to protect the database. This system have gotten positive responses of neuroscience researchers.

關鍵字

神經科學 ； 電腦視覺 ； 果蠅腦 ； WebGL

並列摘要

In this thesis, we build a web-based system for visualizing Drosophila's neuron, neuron groups, and neuropils. This system can help neuroscieance researchers know the relation between neuron and the behavior of Drosophila more directly. The data comes from a lot of states. First, researchers use X-ray to photograph the sinogram of Drosophila's brain. Then, use the technical of image reconstruction to build the 3D volume data. Thirdly, analyze the 3D data to recognize where the neurons are and build their geometry coordination. Professor Chiang's lab in NTHU has built 27K and 16K data in the database by using neuron tracking method. Finally, these neuron data can do the grouping by analyzing the similarity between each neuron's structure. In the previous work of our lab, we have built a database that contains about 2 thousand groups. The purposes of this visualizing system are: showing these neuron data clearly and efficiently, letting researchers operate and query the data conveniently, and building a security log-in system to protect the database. This system have gotten positive responses of neuroscience researchers.

並列關鍵字

Neuronscience ； computer graphic ； Drosophila brain research ； WebGL

參考文獻

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[3] H. Protas S.C. Huang Leow, R. Thompson. Brain warping with implicit representations. In Biomedical Imaging: Nano to Macro, 2004, pages 603–606. IEEE, 2004.

[4] Chuang CC etc. Chiang AS, Lin CY. Three-dimensional reconstruction of brainwide wiring networks in drosophila at single cell resolutio. 2011.

[5] Chen CC& Wu JK& Lin HW. Visualizing long-term memory formation in two neurons of the drosophila brain. pages 335, 678–685. Science, 2012.