Title

腦源性神經營養因數的研究進展

Translated Titles

The Advance Research of Brain-Derived Neurotrophic Factor

DOI

10.6127/JEPF.2004.01.02

Authors

喬德才(De-Tsai Chiau);侯莉娟(Li-Jyuan Hou)

Key Words

腦源性神經營養因數 ; Brain-derived neurotrophic factor BDNF

PublicationName

運動生理暨體能學報

Volume or Term/Year and Month of Publication

1輯(2004 / 09 / 09)

Page #

12 - 18

Content Language

繁體中文

Chinese Abstract

本文旨在闡述腦源性神經營養因數的研究進展及其與運動的關連性。BDNF是從豬腦中分離出來的神經生長因素(Neuro Growth Factors, NGF)之一,在氨基酸水平上具有50%-60%的同源性。神經元內BDNF主要定位於細胞體和軸突。免疫學發現中樞神經系統及周圍神經系統的多種神經元及神經膠質細胞都有BDNFmRNA和蛋白質的出現,研究證實,BDNF在中樞神經系統發育過程中能夠促進神經細胞生長、發育、存活、分化和功能表達,同時也能維持成熟中樞神經系統神經元的正常功能。對學習記憶、保護神經元、抑制細胞凋亡、調節神經元內基因表達,以及抵抗長期大運動量訓練導致的神經元損傷,具有程度上的效果。雖然運動與神經營養因數的關係研究尚未引起史多人的注視,但隨著對BDNF基因表達及調控機制研究的深入,及生理功能的進一步闡明,必將對神經系統發育的研究和神經系統疾病的治療以及運動技能形成機制的揭示帶來新的希望和廣闊的前景。

English Abstract

The purpose of this review was to elaborate the research tendency on brain-derived neurotrophic factor (BDNF) and evaluated the relationship with exercise. BDNF was extract from pig brain. It was one of the neuron growth factors (NOF) and possesses same amino acid up to 50%-60%. The BDNF was located on cell body and axons in a single neuron. The central nervous system (CNS) and peripheral nervous system (PNS) had possession of BDNFmRNA and proteins in many kinds of neuron and neuroglia cell. Study verified the BDNF could promote nervous growth, development, survival, disunite and function express during growth process in CNS. Simultaneously, it could keep the regular function of CNS in the mature neuron also. BDNF bring into effects for memory, protect neuron, restrain cells death, regulate gene performance of neuron and resist the neuron damage result from strenuous exercise. Although, the relationship between exercise and BDNF doesn't cause more attentively, but follow the deep study of BDNF gene performance and regulate mechanism as well as clarify the further physiological function. It would bring new hope and extensive prospects for the study of nervous system growth, disease therapy and motor skill mechanisms.

Topic Category 醫藥衛生 > 預防保健與衛生學
醫藥衛生 > 社會醫學
社會科學 > 體育學
Reference
  1. Adlard, P. A.,Cotman, C. W.(2004).Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression.Neuroscience,124(4),985-992.
  2. Cotman, C. W.,Berchtold, N. C.(2002).Exercise: a behavioral intervention to enhance brain health and plasticity.Trends Neurosci,25(6),295-301.
  3. Ernfors P,Wetmore C,Olson(1990).Identification of cells in rat brain and periphral tissues expressing mRNAfor members of the nerve growth factor family.Neuron,5,511-526.
  4. Escobar, M. L.,Figueroa-Guzman, Y.,Gomez-Palacio-Schjetnan, A.(2003).In vivo insular cortex LTP induced by brain-derived neurotrophic factor.Brain Res,991(1-2),274-279.
  5. Gomez-Pinllla, F.(2001).Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle.Eur J Neurosci,13(60),1078-1084.
  6. Ickes, B. R.,Pham, T. M.,Sanders, L. A.(2000).Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain.Exp Neurol,164(1),45-52.
  7. James, M.,Julie, C.,Hiao, Yan.(1997).Distribution of BDNF protein and mRNA in the normal adult rat CNS.J Neurosci,17,2295-2313.
  8. Kishin, A.,Lshige, Y.(1997).BDNF prevents and reverses adult rat motor neuron degeneration and induces axonal outgrowth.Exp Neurol,144,273-286.
  9. Kplan, D. R.,Hempstead, B. L.,Martin, Z.(1991).The trk protooncogene product: A signal transduction receptor for nerve growth factor.Science,252,554-558.
  10. Lauren(1991).The Role of the Hippocampus in Feedback Regulation of the hypothalamic-Pituitary-Adrenocortial Axis.EndocrineReviews,12(2),118-134.
  11. Lee, J. L.,Everitt, B. J.,Thomas, K. L.(2004).Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation.Science.
  12. Molteni, R.,Wu, A.,Vaynman, S.,Ying, Z.,Barnard, R. J.,Gomez-Pinilla, F.(2004).Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor.Neuroscience,123(2),429-440.
  13. Murphy, P. G.,Borthwick, L. A.,Altares, M.,Gauldie, J.,Kaplan, D.,Richardson, P. M.(2000).Reciprocal actions of interleukin-6 and brain-derived neurotrophic factor on rat and mouse primary sensory neurons. Reciprocal actions of interleukin-6 and brain-derived neurotrophic factor on rat and mouse primary sensory neurons.Eur J Neurosci,12(6),1891-1899.
  14. Neeper.(1996).Physical activity increase mRNA for Brain-derived neurotroplic factor and nerve growth factor in rat brain.Brain Res,726(1-2),49-56.
  15. Pappas, I. S.,Parnavelas, J. G.(1997).Neurotrophins and basic fibroblast growth factor induce the differentiation of calbindin-containing neurons in the cerebral cortex.Exp Neurol,144,302-314.
  16. Ronald,De Kloet(1998).Brain Corticosteroid Receptor Balance in Health and Disease.Endocrine Reviews,19(3),270-301.
  17. Russo-Neustadt.(2001).Physical activy-antidepressant treatment combination: impact on brain-derived Neurotrophic factor and behavior in an animal model.Behav Brain Res,120(1),87-95.
  18. Scaccianoce, S.,Del Bianco, P.,Caricasole, A.,Nicoletti, F.,Catalani, A.(2003).Relationship between learning, stress and hippocampal brain-derived neurotrophic factor.Neuroscience,121(4),825-828.
  19. Thoenen, H.(1995).Neurotrophins and neuronal plasticity.Science,270(5236),593-598.
  20. Tolkovsky, A.(1997).Neurotrophic factors in action-new dogs and new tricks.TINS,20,1-3.
  21. Wu, A.,Ying, Z.,Gomez-Pinilla, F.(2004).The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition.Eur J Neurosci,19(7),1699-1707.
  22. Yan, Q.,Rosenfeld, R. D.,Matheson, G. R.(1997).Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system.Neuroscience,78,431-448.
  23. 牛平、王耀山(2001)。神經營養因數對體外培養多巴胺能神經元營養作用比較研究。中國醫科大學學報,30(6),408-410。
  24. 王謐(2000)。NMDA受體2B亞型(NR2B)研究的分子生物學進展。解剖學研究,22(2),131-135。
  25. 洪新如、鄭鈴(2001)。腦源性神經營養因數對新生大鼠缺氧缺血性腦損傷後腦內脂質過氧化物、乳酸水平的影響。實用兒科臨床雜誌,16(6),392-394。
  26. 孫繼虎、肖杭(2000)。腦源性神經營養因數對海馬神經元NMDA受體功能下調的逆轉作用。中國神經科學雜誌,16(4),349-351。
  27. 張如意、李林、張蘭、王輝、葉翠飛(2003)。參烏膠囊對擬亨廷頓病大鼠行為及腦內神經營養因數的影響。北京中醫藥大學學報,26(4),34-38。
  28. 張潤平(2002)。神經營養因數的作用研究進展。山東醫藥工業,21(2),20-21。
  29. 陳伯英(2002)。C-fos反義寡脫氧核苷酸部分阻斷MCAO大鼠缺血側皮質內BDNF的表達。中國神經科學雜誌,18(4),682-685。
  30. 喬德才、侯莉娟。運動對大鼠腦組織腦源性神經生長因子表達的影響運動對大鼠腦組織腦源性神經生長因子表達的影響,未出版
  31. 趙世剛、姜玉武(2001)。腦源性神經營養因數與海馬苔蘚狀纖維突觸重組的關係。中華醫學雜誌,81(5),283-287。