The Regulation of p53 Isoforms
|Volume or Term/Year and Month of Publication||
2013年论文集（2013 / 05）
92 - 92
The Tp53 gene encodes at least 12 p53 protein isoforms, due to the presence of an internal promoter in intron-4, additional splice variants of intron-9 and the alternative initiation of translation at codon 40, codon 133 and codon 160, which leads to the expression of full-length (FL) p53, p53β, p53γ,△ 40p53, △40p53β, △40p53γ, △133p53α, △133p53β, △133p53γ, △160p53α, △ 160p53β and △160p53γ.These isoforms have been shown to be expressed at the mRNA level, to varying degrees, in a number of different normal and tumor tissues.Their proteins have been shown to have important functions in regulating cell senescence and apoptosis.