Title

Chitosan對已被覆生醫陶瓷Ti6Al4V植入用合金之影響

Translated Titles

Effects of Chitosan on Post Bioceramic Coated Ti6Al4V Implant Alloy

Authors

江啟聖

Key Words

幾丁聚醣 ; 骨細胞 ; 增殖 ; 分化 ; chitosan ; osteoblast ; proliferation ; differentiation

PublicationName

中興大學材料科學與工程學系所學位論文

Volume or Term/Year and Month of Publication

2006年

Academic Degree Category

碩士

Advisor

顏秀崗

Content Language

繁體中文

Chinese Abstract

本研究企圖將幾丁聚醣(chitosan)塗層沈積於已被覆生醫陶瓷之Ti6Al4V上。希望藉由chitosan可被人體吸收、能吸附蛋白質的特性,增加植入材的生物活性,促進骨細胞貼附、增殖與分化的能力。經由XRD、SEM/EDS、AFM、拉伸附著力實驗、陰極極化實驗、浸泡實驗、體外骨細胞培養實驗等探討各種塗層特性。結果顯示, chitosan可以深入HT鍍層的空隙,大幅降低鍍層的表面粗糙度並且增加HA鍍層在拉伸實驗後仍然存在試片表面的比例。由於chitosan擁有許多胺基與氫氧基能吸附模擬體液中的鈣、磷酸根離子的特性,可增加CHT鍍層的生物活性。此外chitosan能避免塗層產生龜裂並提高抗腐蝕性而減少有害人體的金屬離子釋出。體外骨細胞培養實驗包括MTT與ALP試驗顯示chitosan能進一步提升骨細胞在生醫陶瓷塗層的增殖與分化。

English Abstract

To improve the bioactivity, attachment, proliferation and differentiation of osteoblast, the deposition of chitosan was conducted on post biceramics coated Ti6Al4V implant alloy. In the study, the coated specimens were characterized by XRD, SEM/EDS analysis, AFM, adhesion test, electrochemical polarization tests, immersion tests and cell culture. The results showed that chitosan can pentrate and fully cover the porous bioceramics coating and finally result in the decrease of surface roughness. Immersion tests showed that chitosan could improve the bioactivity of coating, avaid the formation of the cracks, raise the corrosion resistance and reduce the metal ion release. The in vitro cell culture including MTT and ALP also revealed the better proliferation and differentiation of osteoblast on chitosan coated specimen.

Topic Category 工學院 > 材料科學與工程學系所
工程學 > 工程學總論
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Times Cited
  1. 黃江瑜(2007)。膠原蛋白對已被覆生醫陶瓷Ti6Al4V植入用合金之影響。中興大學材料科學與工程學系所學位論文。2007。1-98。 
  2. 雷震邦(2014)。熱可塑聚氨酯與氫氧基磷灰石複合材料做為人工髖關節的生物相容性與機械性質分析。中山醫學大學醫學研究所學位論文。2014。1-79。