Siccanin 軟膏對國人皮膚黴菌病之療效評估

Clinical Trial of Siccanin Ointment for Dermatomycoses in Veterans General Hospital-Taipei, Taiwan

任天民(Tien-Ming Jen) ； 黃大齊(Ta-Chi Hwang) ； 解忠燑(Jon-Ton Shei) ； 薛文琦(Wen-Chi Hsueh) ； 薛珍珍(Jen-Jen Shiue)

《Transactions of the Mycological Society of Republic of China》 6卷2期 (1991/06) Pp. 73-89

https://doi.org/10.7099/TMSRC.199106.0073

摘要

從1989年8月至1990年2月，吾人以Siccanin軟膏對20位皮膚黴菌病之門診患者進行外用藥物治療評估。治療期間為3-5週；平均為4.15週茲將研究成果簡述如下：Sicoanin軟膏對各種皮膚黴菌病之有效率為95%(19/20),20位病患中有8位(40%)可評為有效，11位(55%)可評定為約為有效，l位(5%)則經評定為無效。根據吾人研究之初步成果認為Siccanin軟膏對皮膚黴菌病中之皮癬菌病之治療效果較為優良。經黴菌學診斷方法證實係由紅色毛髮癬菌、鬚瘡癬菌及絮狀表皮癬菌所引起之皮癬菌病患者為10位(50%)。因白色念珠菌、白色毛髮芽胞菌、紅色紅泡沫黴菌、薰煙色塵狀菌、分枝胞子黴菌屬、青黴菌屬、塵狀菌屬及念珠菌屬等所引起之皮黴菌病患者為6位(30%)。其餘4位患者(20%)則可能係由未經分離之黴菌及細菌所造成之混合感染性皮膚黴菌病患者。

關鍵字

Siccanin軟膏 ； 皮膚黴菌病 ； 在台灣之臨床及徽菌學之研究

並列摘要

Siccanin, an antifungal antibiotic produced by Helminthosporium siccans was discovered in 1962. It is effective in vitro against various human pathogenic fungi, especially against Trichophyton, Epidermophyton and Microsporum of dermatophytes and a highly virulent fungus; Coccidioides immitis (MIC=0.2-1.6 mcg/ml). From August 1989 to February 1990, 20 patients of chronic dermatomycoses were enrolled at Mycosis Clinic, Department of Dermatology, Veterans General Hospital-Taipei for clinical trial of Siccanin ointment. The follow-up period for each enrollee varied from 3 to 5 weeks. It is considered as effective for 8 of 20 cases (40%), slightly effective for 11 cases (55%) and ineffective for only 1 case (5%) Nineteen cases (95%) showed clinical improvement or cure and 15 cases (75%) showed mycological improvement or cure after Siccanin treatment. The therapeutic effective rate of Siccanin for chronic dermatomycoses is about 95% (19/20).
Ten patients (50%) had dermatophyte infections due to Trichop4yton rubrum, T.mentagropbytes and Epidermophyton floccosum Six cases(30%) had dermatomycoses possibly caused by fungi other than dermatophytes i.e. Candida albicans, Trichosporon beigelii Aspergillus fumigatus, Rhodotorula rubra, Cladosporium sp., Penicilliun Sp., A spergilius sp. and Candida sp. Four cases (20%) of dermatomycoses were perhaps due to some kind of mixed infection of bacteria and non-keratinophilic mold. One case of dermatophytosis presented with tinea cruris and seemed resistant to Siccanin treatment was infected by 2 varieties of T. rubrum showing different reactions to the nutrition test (Jen 1987) with Difco Trichophyton agars.

並列關鍵字

Siccanin ointment "Sankyo" ； dermatomycoses ； Taiwan