貴金屬-磁性奈米複合粒子之製作與表面增強拉曼散射之應用

Single Step Preparation of Noble Metal/magnetic Hybrid Nanoparticles and Their Application in Surface-enhanced Raman Scattering

蔡雅雯(Ya-Wen Tsai)

指導教授 ： 黃俊嬴

高雄醫學大學/生命科學院/醫藥暨應用化學系碩士班/碩士(2017年)

摘要

當物體被粉碎至奈米等級時，其性質會發生相當大的變化，例如高表面積與表面電漿共振。利用其奈米性質，可將其設計成相當好的感測器。
本研究主要的目的是開發一個簡單且快速，並可以大量製備的方法以製作磁性貴金屬奈米複合粒子以作為表面增強拉曼散射(SERS)基材。在此我們以自發性的氧化還原以及共沉澱的方式來製備銀鐵混摻或金鐵混摻的磁性奈米粒子。因貴金屬奈米粒子表面可產生表面電漿共振效應(SPR)故其可當成良好的表面增強拉曼散射基材，且因我們製造出的奈米粒子帶有磁性，可以較易用來控制其在水溶液中的行為，將其聚集或分散。以磁性的奈米粒子做為感測器除有磁性這個優點以外還具有其他優點，例如其有較大的表面積、可以快速分散也可以用磁鐵將其快速聚集、縮短偵測時間、可以懸浮在溶液中，以增加吸附的效率等。
為了使偵測靈敏度提升，我們將此基材再做進一步表面修飾，包含在基材的表面上修飾具有硫醇鍵(-SH)的長碳鏈分子1-dodecanethiol以及11-mercaptoundecanoic acid等等分子，利用這些長碳鏈分子的疏水性質，即可去偵測對環境有危害的揮發性有機化合物(VOCs)，使本研究中所製作的複合式奈米基材可以有更實際的應用性。

關鍵字

表面增強拉曼散射 ； 貴金屬磁性奈米粒子

並列摘要

In contrast to bulk materials, nanonized materials have many extraordinary properties, such as high surface area, quantum effects, surface plasmon resonance (SPR), and so on. Owning these unique properties, nanonized are applied widely in diverse areas.
On the other hands, the applications of magnetic nanoparticle were investigated extensively in recent years due to their fascinating characterizations such as high surface to volume ratio, easy to be attracted and re-dispersed, paramagnetism, and so on. The applications of magnetic nanoparticles are diverse, including catalyst, medical imaging, separation, extraction, sensing, and many other fields.
In this study, we used a simple but facile way to prepare silver/gold nanoparticles doped magnetic nanoparticles (AgMNPs/AuMNPs) by the spontaneous oxidation-reduction/ co-precipitation method. The preparation can be achieved in a single step and the prepared AgMNPs/AuMNPs were utilized as the substrates for the surface-enhanced Raman scattering (SERS). The resulting particles are magnetic and can be easily used to control the activity of nanoparticles in solution.
Furthermore, the prepared AgMNPs/AuMNPs were modified with 1-dodecanethiol or 11-Mercaptoundecanoic acid and were used for the detection of hazardous substance in the atmosphere by the way of hydrophobic interaction between the long alkane chain-thiol-NPS and toxic volatile organic compounds (VOC). The results indicated that the AgMNPs/AuMNPs prepared in this study have the potential in practical applications.

並列關鍵字

SERS ； Noble Metal/magnetic Hybrid Nanoparticles

參考文獻

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