Immunological Studies of Children with Anaphylactoid Purpura

兒童期過敏性紫斑的免疫學研究

林世強(Shih-Chiang Lin) ； 蔡銘哲(Ming-Jer Tsai) ； 黃妙慈(Miao-Tsu Huang) ； 吳冠勳(Kuan-Hsun Wu) ； 王玲華(Ling-Hua Wang) ； 江伯倫(Bor-Luen Chiang)

《Acta Paediatrica Sinica》 39卷4期 (1998/08) Pp. 247-252

https://doi.org/10.7097/APS.199808.0247

摘要

Anaphylactoid purpura is a small-vessel, vasculitic disease of unknown etiology, but it is thought to be caused by an immunoglobulin-mediated inflammatory process. To study the immunological profiles of local anaphylactoid purpura patients, during the period from October 1996 to October 1997 with 17 patients, (6 boys and 11 girls), (aged 3 years to 17 years, mean age: 7.9 years), with anaphylactoid purpura who visited National Taiwan University Hospital. Immunological studies were performed in 17 patients and 20 age-matched healthy controls. Higher C3 was noted in patients (126.2±26.7 mg/dL) than in the control group (116.1±16.7 mg/dL), although without statistical significance (P=0.307). C4 levels of patients were significantly higher in patients than control group (38.6±13.4 v.s. 23.7±6.9 mg/dL, P＜0.001). There were no sign4JIcant differences in the JgG and 1gM levels between patient and control groups. In contrast, the IgA levels of patient were significantly higher than that control groups (293.1±102.9 vs. 179.8±71.0mg/dL, P=0.001). The serum level of TGF-β1 of patients was higher than that of the control group although not statistically significant (44.1±27.3 v.s. 29.9±19.0ng/mL, p=0.067). A significantly higher percentage of T cells was noted in anaphylactoid purpura patients than controls (71.5±9.2% v.s. 65.0±6.3%, P0.016). However, no sign/lcant difference was found in other subpopulations of lymphocytes. These basic immunological profiles may be helpful for further work on the pathogenesis of anaphylactoid purpura.

關鍵字

過敏性紫斑 ； 補體 ； 免疫球蛋白 ； TGF-β1 ； 淋巴球次群

並列摘要

Anaphylactoid purpura is a small-vessel, vasculitic disease of unknown etiology, but it is thought to be caused by an immunoglobulin-mediated inflammatory process. To study the immunological profiles of local anaphylactoid purpura patients, during the period from October 1996 to October 1997 with 17 patients, (6 boys and 11 girls), (aged 3 years to 17 years, mean age: 7.9 years), with anaphylactoid purpura who visited National Taiwan University Hospital. Immunological studies were performed in 17 patients and 20 age-matched healthy controls. Higher C3 was noted in patients (126.2±26.7 mg/dL) than in the control group (116.1±16.7 mg/dL), although without statistical significance (P=0.307). C4 levels of patients were significantly higher in patients than control group (38.6±13.4 v.s. 23.7±6.9 mg/dL, P＜0.001). There were no sign4JIcant differences in the JgG and 1gM levels between patient and control groups. In contrast, the IgA levels of patient were significantly higher than that control groups (293.1±102.9 vs. 179.8±71.0mg/dL, P=0.001). The serum level of TGF-β1 of patients was higher than that of the control group although not statistically significant (44.1±27.3 v.s. 29.9±19.0ng/mL, p=0.067). A significantly higher percentage of T cells was noted in anaphylactoid purpura patients than controls (71.5±9.2% v.s. 65.0±6.3%, P0.016). However, no sign/lcant difference was found in other subpopulations of lymphocytes. These basic immunological profiles may be helpful for further work on the pathogenesis of anaphylactoid purpura.

並列關鍵字

anaphylactoid purpura ； complement ； Immunoglobulin ； TGF-β1 ； lymphocyte subsets