- 期刊
- Ahead-of-Print
Higher serum magnesium concentration is associated with lower hearing thresholds and risk of hearing loss among a Chinese population
摘要
Background and Objectives: Hearing loss is a sensory impairment caused by genetic and environmental factors. Previous epidemiological studies of magnesium intake and hearing loss have been conflicting. Methods and Study Design: We investigated the association between serum magnesium concentrations and hearing loss in a population in Zhejiang region in China. A cross-sectional study of 3,267 participants aged 18 years and above from five hospitals was conducted from October 2016 to May 2018. Audiometric examination was conducted, and hearing thresholds as pure-tone averages (PTAs) at speech (0.5, 1, 2, and 4 kHz) and at high frequencies (3, 4, and 6 kHz) were computed. Magnesium concentrations were measured using an inductively coupled plasma mass spectrometer. Results: We found a negative association between magnesium levels and hearing loss from lower PTA to high PTA by linear regression analysis. After adjustment of potential confounders, participants in the highest quartile of magnesium had lower PTA (quartile 4: -1.89%; 95% confidence interval (CI: -3.07 to -0.701; p=0.022) and high PTA (quartile 4: -3.05%; 95% CI: -4.64 to -1.46; p=0.005) than those in the lowest quartile. Logistic regression analysis showed a dose-dependent reduction in the odds of high frequency hearing loss across quartiles of magnesium. In model 3, after adjusting for all potential confounders, participants with the highest quartiles of magnesium had a 54.0% (OR: 0.460; 95% CI: 0.339-0.587) reduction in the odds of high frequency hearing loss. Conclusions: Higher levels of whole blood magnesium in this population were associated with lower hearing thresholds and risk of hearing loss.
延伸閱讀
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