本文以放射免疫檢定法測定三百個正常中國孕婦血中絨毛膜性腺激素之值。由此得以做為基準而異常妊娠之值做比較。我們的結顯示此正常曲線與國內外之報告相近;在妊娠九週時連最高值(100.4 IU/ml),而在十五週以後維持在10 lU/ml附近。我們也測定不正常妊娠絨毛膜性腺激素之變化情形。對十六個先兆性流產病人之測定觀察顯示只靠絨毛膜性腺測定並不能準確地預測妊娠的結果。此外,根據我們對十二個過期流產和九個子宮外孕病人的測定觀察;發現血中絨毛膜性腺激素之值在這些狀況下呈現有意義的下降。因此絨毛膜性腺激素的測定應有助於吾人對這些疾病的診斷與處理。在本研究中,絨毛膜性腺激素之測定對於萄葡胎妊娠之診斷及追蹤上的價值再次得到證實。在十一個子宮頸癌的病患,我們發現了兩個病患可測得絨毛膜性腺激素;更進一步的研究成有助於吾人對癌症之早期診斷並叫做為治療後追蹤檢查之指標。
The serum levels of HCG in 300 normal pregnant women were measured by beta-subunit HCG kit. The peak value was 100.4 IU/ml at the 9th week of gestation. Then the value dropped and plateaued around 10 IU/ml after the 15th week.The HCG titer was also measured in 16 cases of threatened abortion, 12 cases of missed abortion, 9 cases of ectopic pregnancy, 10 cases of trophoblastic disease and 11 cases of carcinoma of cervix. The use of HCG measurement in these conditions and its limitation were discussed.