Mechanical circulatory support devices are effective in saving patients from failing hearts. They are different in the degree of support and in the invasiveness of device insertion. Physicians in charge decide the timing of device application and choice of an appropriate device in a specific clinical setting. Therapist should understand 1) the basic types of the circulatory support; 2) the functions of these devices; 3) the mechanisms of the devices and precautions while working or exercising with patients having such assistive devices. This article provides the overviews of the indications, complications, and commonly available models of short-term and long-term supportive devices. The operative procedures of implantable ventricular assistive device (VAD) and total artificial heart (TAH) and postoperative recovery are described. The TAH devices are often have venous return sensitivity less than optimal and limitations in maximal flow. The other physiological changes related to TAH are also addressed. Experiences in many medical centers around the world have made possible to optimize patients' general condition and improve their chance of survival. Some of these patients have been discharged from hospital and survived over 1 year. Researches have been undergone even no devices are approved for permanent implantation at the present time.