Extraction of an Arterial Stiffness Index from Oscillometry

Shing-Hong Liu ； Jia-Jung Wang ； Zu-Chi Wen

《Journal of Medical and Biological Engineering》 27卷3期 (2007/09) Pp. 116-123

並列摘要

The purpose of this study was to investigate a non-invasive method for estimating a brachial artery stiffness index. The method applied oscillometric amplitude as an indicator of intravascular volume change, and variation in cuff pressure to specify the difference in transmural pressure. In order to increase the stability of repeated measures, data were further analyzed by a recursive regression approach that modeled the correlation between the oscillometric amplitude and cuff pressure. Pressure difference between the two pressure levels respectively corresponding to 80% of peak amplitude in the oscillometric pulse amplitude envelope was denoted as a new arterial stiffness index (ASI). The study included 28 subjects, 4 healthy and 24 suffering from cardiovascular disease. Systemic arterial compliance in all subjects was calculated as the division of stroke volume measured with an M-mode echo-tracking device and pulse pressure with a column sphygmomanometer. Linear regression analysis showed a significant correlation between the ASI and systemic arterial compliance (r=0.77, SEE=4.34, p＜0.0001) for all subjects. In conclusion, the oscillometry-based ASI may be useful not only in non-invasively evaluating the systemic arterial compliance but also in quantitatively describing the wall stiffening of peripheral arteries.

並列關鍵字

Arterial stiffness ； Oscillometry ； Recursive regression approach ； Systemic arterial compliance