犬隻血管壁機械特性的超音波探討

為探討年齡及血壓對血管壁機械特性的影響，實驗犬隻於麻醉狀況下，以非侵入性超音波儀檢測收集總頸動脈、膊動脈、橈動脈、股動脈與脛動脈等管壁搏動的連續影像，以及血管壓力波形與血壓數據，所有資料以血管指數軟體進行分析，分析內膜中層厚度、管壁硬度與能量消散比率的變化。結果發現：老犬、成犬的管壁厚度較厚，管徑大的血管管壁較厚。血管硬度會隨年齡而增加，老犬、成犬血管硬度以總頸動脈最高，前肢動脈次之，後肢動脈最低。血管壁能量消散比率則以後肢脛動脈較高，管壁硬度增加時，能量消散比率減少。若投予Levophed使血壓上升時，可見膊動脈管壁厚度、硬度的增加，並因管壁黏滯性增加致能量消散比率上升。本研究利用動物模式檢測血管壁機械特性，可驗證檢測分析方法，並落實其臨床應用於人醫和動物醫學。

關鍵字

超音波；血管壁機械特性；內膜中層厚度；血管壁硬度；能量消散比率

並列摘要

A canine model was used to detect the effects of age and blood pressure on the mechanical property of arterial wall. After the dogs were anesthetized, the consecutive images of various arteries including the common carotid, brachial, radial, femoral, and tibial arteries were examined by non-invasive ultrasonography. The blood pressure and waveform of vascular pressure were collected simultaneously. All image data were analyzed by the vascular index (VI) software to examine the changes of vascular intima-media thickness (IMT), stiffness, and energy dissipation ratio (EDR). The values of IMT increased in older dogs and the vessels with larger calibers. The vascular stiffness increased with ages, and was higher in common carotid artery, and lower in the vessels of forelimbs and hindlimbs. The EDR of the tibial artery was higher than that of all other vessels, and the EDR decreased when the stiffness increased. The IMT, vascular stiffness, and EDR all increased when blood pressure was elevated by administration of Levophed. The increase of vascular viscosity caused by Levophed likely led to the increase of EDR. These results from animal study can verify the methodology for clinical applications.

並列關鍵字

Ultrasonography ； mechanical properties of vascular wall ； intima-media thickness ； vascular stiffness ； energy dissipation ratio

國際替代計量

犬隻血管壁機械特性的超音波探討

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