Weekly Doxorubicin with Tegafur-Uracil Slowed Progression of Metastatic Hepatocelluar Carcinoma in Schizophrenia Patients

轉移性肝癌合併精神分裂病患之治療經驗之分享：使用每周性速溶艾黴素（Doxorubicin）及友復膠囊（UFUR）

張悅詩(Yueh-Shih Chang) ； 黃仁聖(Jen-Seng Huang) ； 葉光揚(Kun-Yun Yeh)

《台灣癌症醫學雜誌》 29卷4期 (2013/10) Pp. 206-211

https://doi.org/10.6323/JoCRP.2013.29.4.6

摘要

精神分裂症病患合併腫瘤之治療是複雜的，除了考慮療效，更多需要重視的是精神疾病之控制及藥物與藥物間的副作用。本文分享兩位轉移性肝癌合併精神分裂患者之肝癌治療經驗，在使用每周性速溶艾黴素（Doxorubicin）及友復膠囊（UFUR）之控制下，除了延長生存時間，也有好的病患之藥物順從性及忍受性，此外，初步結果顯示不會干擾病患精神狀況及疾病控制。此組合性治療可提供轉移性肝癌合併精神分裂之患者除了蕾莎瓦（Sorafenib）之外之另一個選擇。

關鍵字

轉移性肝癌 ； 精神分裂症 ； 化學治療

並列摘要

We herein reported on 2 schizophrenia patients comorbid with metastatic hepatocellular carcinoma (HCC) who received palliative chemotherapy using weekly doxorubicin (30 mg/m^2 on day 1, day 8 and day 15 every 4 weeks) and tegafur-uracil (400 mg/day, 5 days every week). After 6 months of treatment, the metastatic HCC responded favorably to treatment and reached a stable disease status (according to the World Health Organization criteria), and survival extended over 18 months for both patients. The chemotherapy toxicity was well-tolerated and psychotic symptoms were controlled throughout the treatment period. Close cooperation between oncologist and psychiatrist is helpful to most effectively pursue the chemotherapy schedule and obtain survival benefit. This combination chemotherapy could be a treatment alternative for metastatic HCC in schizophrenia patients who were unsuitable for Sorafenib use.

並列關鍵字

metastatic hepatocellular carcinoma ； schizophrenia ； chemotherapy