This is a 34-year-old female who has suffered from pompholyx for more than 5 months. Due to debilitating effects of western medical treatment, she visited our hospital for help on 106/7/24. We prescribed Po-Hu Chia-Jen-Tsen-Tang Powder with frequency of 3 packs a day in combination with the bathing formula of Sophora flavescens Aiton with 1 times a day after inspection, auscultation, olfaction, inquiry and palpation based on the theory of traditional Chinese medicine. After taking Chinese herbal medicine in combination with bathing formula, vesicles in her limbs disappeared and the symptoms of itch improved. There is no case report about treating pompholyx disease with Po-Hu Chia-Jen-Tsen-Tang Powder in combination with the bathing formula of Sophora flavescens Aiton, so we presented this case for clinical reference.