- 期刊
- Ahead-of-Print
A single-nucleotide polymorphism in transferrin is associated with soluble transferrin receptor levels in Chinese adolescents
並列摘要
Background and Objective: Associations between genetic variants in the hepcidin regulation pathway and iron status have been reported in previous studies. Most of these studies were conducted in populations of European descent and relatively few studies have been conducted in Chinese populations. In this study, we evaluated associations between single-nucleotide polymorphisms (SNPs) in the hepcidin regulation pathway and the levels of serum ferritin (SF) and soluble transferrin receptor (sTfR) in Chinese adolescents. Methods and Study Design: In total, 692 students from rural boarding schools were selected from six cities in China. The participants were divided into case and control groups according to criteria for SF and sTfR. Furthermore, 33 SNPs in TMPRSS6, TF, TFR2, BMP2, BMP4, HJV, CYBRD1, HFE, IL6, PCSK7, HAMP, KIAA1468, and SRPRB were selected. Associations between the genetic variants and SF or sTfR were detected. Results: For SF, rs4820268 in TMPRSS6 was associated with an SF ＜25 ng/mL status. Carriers of the G/G genotype of rs4820268 exhibited significantly lower SF levels than A allele carriers did (p = 0.047). For sTfR, rs1880669 in TF, rs4901474 in BMP4, and rs7536827 in HJV were significantly associated with an sTfR ≥4.4 mg/L status. However, in general linear model analysis, after adjustment for age, sex, and location, only rs1880669 exhibited a stable association with higher sTfR levels (p=0.032). Conclusion: We found rs4820268, in TMPRSS6 that was associated with a low SF level, as previously reported, and a new association between 1880669 in TF and sTfR.
延伸閱讀
- Piao, W., Wang, L., Zhang, T., Wang, Z., Shangguan, S., Sun, J., & Huo, J. (2017). A single-nucleotide polymorphism in transferrin is associated with soluble transferrin receptor in Chinese adolescents. Asia Pacific Journal of Clinical Nutrition, 26(6), 1170-1178. https://doi.org/10.6133/apjcn.112016.04
- Lin, C. H., Ho, C. Y., Liu, C. S., Lin, W. Y., Li, C. I., Yang, C. W., Bau, D. T., Li, T. C., & Lin, C. C. (2012). Influence of Adiponectin Gene Polymorphisms on Adiponectin Serum Level and Insulin Resistance Index in Taiwanese Metabolic Syndrome Patients. The Chinese Journal of Physiology, 55(6), 405-411. https://doi.org/10.4077/CJP.2012.BAA081
- Yao, N. J. (2014). Associations of Single Nucleotide Polymorphisms in Dopamine-Related Genes with Developmental Variations in Preterm and Term Children [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2014.01315
- Wu, F. L. L., Chen, Y. R., Lin, M., Chern, H. D., & Shen, L. J. (2008). Variability in the Frequency of Single Nucleotide Polymorphisms of N-acetyl Transferase 2 (NAT2) Gene among the Different Ethnic Groups in Taiwan. 藥物食品分析, 16(5), 15-20. https://www.airitilibrary.com/Article/Detail?DocID=10219498-200810-16-5-15-20-a
- Wu, L., Gao, L., Zhao, X., Zhang, M., Wu, J., & Mi, J. (2017). Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children. International Journal of Endocrinology, 2017(), 1-5. https://doi.org/10.1155/2017/6437542