Performance Evaluation of the Triumph SPECT Small-Animal Imagine System

David Tat-Wei Tan ； Ren-Shian Liu ； Jyh-Cheng Chen

《核子醫學雜誌》 25卷2期 (2012/03) Pp. 68-75

https://doi.org/10.6332/ANMS.2502.005

並列摘要

Background: Triumph SPECT system utilizes the CZT (Cadmium, Zinc and Telluride) semiconductor detector to replace the traditional Nal(TI) scintillation detectors for gamma-ray detection. It's usually proposed in molecular biology and drug development imaging research. The aim of this work was to evaluate the initial performance of a small animal molecular imaging system of micro-single photon emission computed tomography subsystem (microSPECT).Method: The SPECT spatial resolution was evaluated by using multiple line source and equipped with a single pinhole collimator with the aperture size of 0.5 mm. The system sensitivity was measured by using a point source to evaluate both of parallel-hole and single pinhole collimator based SPECT. Then, the spatial linearity of the single pinhole collimator based SPECT was measured by different radio-concentration of Tc-99m solution. The integral and differential uniformity were measured with a point source placed at the center of the FOV. An ultra-micro hot spot phantom was scanned with single pinhole and multiple-pinhole SPECT.Results: The spatial resolution measured with a line source and at a radius of rotation (ROR) of 30 mm was 0.91 mm full width half maximum (FWHM). The sensitivity of three sets of detectors using parallel-hole collimator at a ROR of 120 mm was 984.04, 1063.45 and 1049.91 cps/MBq/ml. The sensitivity that equipped with 0.5 mm pinhole aperture at a ROR of 30 mm was 83.5, 160.12 and 165.51 cps/MBq/ml. The spatial linearity of 0.5 mm pinhole aperture performed a significant correlation coefficient of r = 0.990. The integral and differential uniformity among three sets of CZT detectors were 4.93% and 4.48%, and 5.54% and 4.48%, and 5.07% and 3.85%, respectively. The single pinhole collimator with 0.5 mm aperture could separate clearly the 1.00 mm hot spots. However, multiple pinhole collimator equipped with 1.0 mm aperture could only distinguish 1.75 mm hot spots.Conclusion: According to our results, the micro-single photon emission computed tomography subsystem (microSPECT) is suitable for in vivo small animal molecular imaging research.

並列關鍵字

linearity ； microSPECT ； spatial resolution ； uniformity