The aim of this investigation is to determine the temporal effect of different modes (frequency and intensity) of electrical nerve stimulation. Laser-evoked dorsal column potentials (LEDCP) are used as an objective measurement to study the effect of peripheral stimulation in spinal cord. The experimental animals were made a spinal transection at the T7-8 level. Laser stimulation was applied to the plan- tar surface of the foot. Four different modes of electrical nerve stimulation were applied to the common peroneal nerve be protected cuff electrodes wrapped around the nerve. Single stimulation with low intesity (5 times threshold; LIS) and single stimulation with high intensity (100-200 times threshold; HI-S) were applied for only one sqaure wave stimulation with duration of 0.5 msec. High frequency (100Hz)-low intensity (5 times threshold) stimulation (HFLI), and low frequency (2Hz)-high intensity (200 times threshold) stimulation (LFHI) were applied as a continuous train of square wave stimulation lasting for 1 sec and 5 secs respectively. All these four modes of electrical stimulation were applied through a protected cuff electrode. Each mode of stimulation preceedes the testing laser stimulation at different intervals (0, 50, 100, 250, 500, 1000) at different trials. Single stimulation, neither low intensity (LI-S) nor high intensity (HI-S) demonstrated significant suppression effect on LEDCPs. FIFLI elicits partial inhibition on the LEDCPs at the interval of 0 msec. LFHI elicits more dramatic inhibition at a wider range of intervals (about a few secs). Our results demonstrate different modes of electrical stimulation with a few seconds of duration produced fast onset (within msecs) and short lasting (within seconds) of inhibition in the spinal cord. The significance of this study is the demonstration of the suppression of the spinal activity that is related to the intensity and frequency of the electrical stimulation.