The helper T-cell (CD4+) and the suppressor T-cell (CD8+) holds the key position in the immunity system. In this review, we first investigated relations the exercise and the immunity function, the second to analyze the research effects of exercise influence of and CD4+/CD8+ ratio experiment result to CD4+ and the CD8+. The result revealed that the rule of moderate and submaximal exercise, may promote the CD4+/CD8+ ratio, increases the immunity; acute and exhaustion exercise, in vivo CD4+ and the CD8+ proportion and the quantity redistribute, causes the immunity system suppression, the immunity to reduce, increase upper respiratory tract infection probability. We also recommended to the further research about the test effects of the future clinical training plan monitoring the target, the achievement draws up the exercise prescription the basis, elaborated the possible interactive mechanism to refer the trying in vivo immunity target, reduces in vivo harmful factor the production. Simultaneously will suggest further investigates, the definite movement to the health and the disease impact, the connection and the correlation mechanism, will be able to have the suitable benefit regarding the immunity system turning point understanding and the all the people healthy body.