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Human Growth Hormone Responses to Insulin-Induced Hypoglycemia, Exercise and Propranolol with exercise in Children

小兒對胰島素引起之低血糖,運動及口服Propranolol後運動激發人體生長素分泌之研究

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Abstracts


本研究針對38位非人體生長素缺乏所致侏儒,7位人體生長素缺乏所致侏儒及10位健康正常小兒,觀察其對胰島素引起之低血糖;運動及口服propranolol後運動引發人體生長素分泌之情形,結果如下: 胰島素引起之低血糖激發生長素分泌之能力比運動及口服propranolol後運動爲大。所有10位正常兒童對於每公斤0.1單位胰島素之靜脈注射都能有正常之生長素分泌反應。 10位健康小兒當中有8位(80%);及38位非生長素缺乏所致侏儒當中有30位(78.5%)對於運動有正常之生長素分祕反應。33位非生長素缺乏之侏儒在運動前60分鐘給予口服每公斤0.5mg之propranolol,結果30位(90.9%)對運動有正常之生長素分泌反應。 胰島素引起之低血糖激發生長素分泌之能力雖較大,但其操作麻煩且病人受很多苦。propranolol確能加強運動激發生長素分泌之效果,賓驗前給予口服propranolol可以增加運動實驗之臨床可用性。

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Parallel abstracts


Plasma human growth hormone (HGH) responses to insulin-induced hypoglycemia, exercise and propranolol with exercise were assessed in 38 non-HGH-related short children, 7 growth hormone deficient dwarfs and 10 healthy normal children. Insulin-induced hypoglycemia is the most potent stimulus to HGH secretion. All 10 normal children responded to the insulin-induced hypoglycemia with the peak plasma HGH levels of 8ng/ml or more. Eight of (80%) the 10 normal children and 30 (78.5%) of the 38 non-HG H-related short children responded normally to the exercise tests. When propranolol was given 60 minutes before the exercise test, 30 (90.9%) of the 33 children responded normally. Propranolol enhances the HGH response to exercise. It increases - the number of positive responders and the degree of responses to the exercise test.

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