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The chemical components and pharmacological effects of a Chinese herbal drug Wu-Chu- Yu, the dry unripe fruit of Evodia rutaecarpa (Juss.) Benth (Evodiae Fructus, E.F.), have been studied by us since 1976. Totally, thirty-eight chemicals are isolated and identified from Evodiae plants in Taiwan. Among them, eight (7-hydroxyrutaecarpine, and 7 novel aceptophenones) are characterized as new chemicals. Under bioassay directed fractionation, three compounds, dehydroevodiamine (DeHE), evodiamine (Evo) and rutaecarpine (Rut) are isolated and studied pharmacologically. Further studies demonstrate that DeHE produces a hypotensive and bradycardic effecds in SHR, but not in WKY rats. However, higher doses of Rut (2.5-20 mg/kg, i.p.) increase blood pressure in conscious WKY rats but not in SHR. Evo also produces hypotensive and tachycardiac effects in conscious SHR but not in WKY rats. Endothelium activation and receptor-mediated Ca2+ channels inhibition in the vascular smooth muscle are involved in the vasorelaxant effect of DeHE, Evo and Rut. The vasorelaxant effect of Rut is 100% endothelium dependent in the aorta but only 65-70% in mesenteric artery. Evo exerts 50% endothelium dependence in aorta and 20% in mesenteric artery. Vasorelaxant effect of DeUE in mesenteric artery is 20% endotheliumdependent, but not endothelium dependent in the aorta. Recently, the anti-amnesia effect of DeHE in intracerebroventricular β-amyloid peptide injected mice is shown. Studies also show the effect of E.F. and its bioactive components on septic-shock rats, on rabbit corpus cavernosum, and on testosterone and aldosterone secretion in rat testicular interstitial cells and Zona glomerulosa cells. The interaction of E.F. and its bioactive components between various drugs metabolizing enzymes is further demonstrated.

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柯漢傑(2007)。吳茱萸活性成分之研究〔博士論文,臺北醫學大學〕。華藝線上圖書館。https://doi.org/10.6831/TMU.2007.00017

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