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Cutaneous Phaeohyphomycosis Caused by Exophiala jeanselmei-Successful Treatment with the Combination of Itraconazole, Topical Heat Followed by Additional Cryotherapy-

Exophiala jeanselmei所致皮膚暗色絲孢菌病-成功以Itraconazole結合局部熱治療及冷凍治療-

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Abstracts


隨著免疫抑制劑的廣泛使用,以及診斷學的進步,Exophiala所引起的表皮暗色絲孢菌病在近年來有越來越多的病例報告。然而,至今仍然沒有一標準有效的治療方式。通常療程冗長結果令人沮喪,特別是無法切除的大片疣狀硬塊。 吾人報告一例發生在七十五歲女性,由Exophiala jeanselmei所致的表皮疣狀暗色絲孢菌病。成功的以口服itraconazole加上熱敷包熱治療,再施予局部液態氮冷凍。達到臨床上治癒且無并發症或破壞性疤痕產生。

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Phaeohyphomycosis caused by Exophiala species has recently been reported with increasing frequency with wide-spread use of immunosuppressive agents and improved laboratory methods for making the diagnosis. However, no standard therapeutic regimens have been established to date. Often, treatment is frustratingly prolonged, especially for larger lesions when surgery is not feasible. We report a case of cutaneous verrucous phaeohyphornycosis caused by Exophialajeanselmei in a 75-year-old female. She was successfully treated as an outpatient with a combination of oral itraconazole and topical heat therapy with disposable pocket warmers, followed by cryotherapy. A complete resolution without complications or disfigurement was achieved.

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