This was a case of a 47-year-old male patient who had long-term insomnia for more than twenty years and troubled with headache. He had gone to see a doctor and diagnosed with neurosis, and some antipsychotic drugs and pain killers were given for treatment. Then, he was accidentally examined to suffer from benign tumor of brain, and accepted the operation of brain tumor excision. However, the insomnia problem was continued, and he still took the antipsychotic drugs for sleeping. Therefore, he started going to Chinese Medicine OPD for help, and his insomnia syndrome was obviously improved and he also even stopped taking any other antipsychotic drugs after several times of Chinese Medicine treatment. We demonstrated the experience in this case report for clinical reference and application.