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Hepatoprotective Effect of Aqueous Acetone Extract of Sida alba L. (Malvaceae) Against Alcohol Induced Liver Damage in albinos Wistar Rats
Parallel abstracts
The present study was conducted to evaluate the hepatoprotective effects of aqueous acetone extract of Sida alba. (Malvaceae) an herbal plant used in Burkina Faso to treat traditionally hepatics affections in albinos Wistar rats. Animals were treated by gavage during 28 days with different doses of aqueous acetone extracts of Sida alba. (75, 100, 150 mg/kg) suspended in 35% ethanol. Control groups received alcohol 35% and water. In vivo administration of 35% ethanol for 28 days results an activity of liver marker enzymes (AST, ALT, ALP), glucose, triglycerides, total cholesterol, total bilirubin and direct bilirubin in serum as compared with rats which received water (control water). However, administrations of 35% ethanol along with aqueous acetone extract decreased the activities of liver markers enzyme in serum comparatively to the control water group (p＜0.05 or p＜0.01). We noticed that extract at a dose of 150 mg/kg was highly effective than 75 and 100 mg/kg body weight compared to the control water group (ALT and ALP; p＞0.05 and p＜0.05). This study revealed that Sida alba presents a hepatoprotective potential and this plant could be traditionally exploited in the treatment of affection hepatics.
Parallel keywords
Albinos Wistar rats ； biochemical parameters ； hepatoprotective potential ； Sida albaRead-around
- Konaté, K., Ouédraogo, M., Ouattara, M. B., Dibala, I. C., Mavoungou, J. F., Lepengué, A. N., Souza, A., Batchi, B. M., & Nacoulma, O. G. (2012). Hepatoprotective Activity of Aqueous Acetone Extract from ＂Cienfuegosia digitata＂ Cav. (Malvaceae) Against Alcohol Hepatotoxicity in Albinos Wistar Rats. Research Journal of Applied Sciences, Engineering and Technology, 4(12), 1637-1641. https://www.airitilibrary.com/Article/Detail?DocID=20407467-201206-201510230013-201510230013-1637-1641
- Widyaningsih, T. D., & Adilaras, P. (2013). Hepatoprotective Effect of Extract of Black Cincau (Mesona palustris BL) on Paracetamol- Induced Liver Toxicity in Rats. Advance Journal of Food Science and Technology, 5(10), 1390-1394. https://doi.org/10.19026/ajfst.5.3115
- Konda, V. R., Arunachalam, R., Eerike, M., K, R. R., Radhakrishnan, A. K., Raghuraman, L. P., Meti, V., & Devi, S. (2016). Nephroprotective effect of ethanolic extract of Azima tetracantha root in glycerol induced acute renal failure in Wistar albino rats. Journal of Traditional and Complementary Medicine, 6(4), 347-354. https://doi.org/10.1016/j.jtcme.2015.05.001
- 洪金足（2006）。THe hepatoprotective effects of the water extract of Solanum nigrum L.on hepatic damages induced by Carbon Tetrachloride in rats〔碩士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2006.00105
- Kannan, N., Sakthivel, K. M., & Guruvayoorappan, C. (2013). Protective Effect of Acacia nilotica (L.) against Acetaminophen-Induced Hepatocellular Damage in Wistar Rats. Advances in Pharmacological Sciences, 2013(), 195-203. https://doi.org/10.1155/2013/987692