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Muscle Aging, Calorie Restriction and Resveratrol

Abstracts


As aging population increases dramatically, body functional limitation and loss of independence in the elderly become urgent issues. Skeletal muscles are the main tissues responsible for the function of daily activity. Loss of muscle mass and strength often render the elderly loss of independence. In addition to exercise, it is always interesting to know whether diet retards muscle aging. Calorie restriction (CR) is consistently shown to delay the onset of aging-related pathologies and extend healthspan on a range of model organisms. It was also found to attenuate aging-related muscle loss in both rodents and primates. Mechanisms underlying the beneficial effects of CR include reduced anabolic signaling and improved metabolism as well as stress-responses. Although CR delays animal aging, it is difficult for most individuals to maintain a calorie-restricted diet. Therefore, discovering CR mimetics that target physiological mediators of CR and produce similar physiological effects of CR is an important topic. Resveratrol, for example, is one CR mimetics that has received lots of attention. The hallmark of physiological response of resveratrol is improving insulin sensitivity, increasing mitochondrial function and decreasing oxidative stress, especially in animal models with significant impaired metabolism and elevated oxidative stress. This study reviewed aging-related changes of skeletal muscles and current evidences regarding the effects of CR and resveratrol on muscle aging.

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