- 學位論文
治療計畫程式THORplan與SERA用於硼中子捕獲治療復發性頭頸癌劑量計算結果之比較
Comparison of Dose Calculation using Treatment Planning System THORplan and SERA for Clinical Trial of Boron Neutron Capture Therapy for Recurrent Head and Neck Cancer
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摘要
清華大學研究團隊與台北榮民總醫院於2010年開始進行國內硼中子捕獲治療復發性頭頸癌，迄今完成20位病人之照射治療。本研究目的為分析所使用之治療計畫程式THORplan與日本及芬蘭臨床治療使用的SERA治療計畫程式兩者劑量計算結果之差異。 THORplan使用的射源y09其角度分佈有空間依存性，然而SERA無法使用中子群隨空間變化的角度分布之射源，故先採用角度分佈無空間依存性的射源50c進行THORplan與SERA之計算結果的比較。結果顯示，THORplan在腫瘤D80劑量率比SERA多4%，故預估照射時間少4%，正常組織最大劑量率少3%。由於照射時間少4%，THORplan求得正常組織最大劑量比SERA小5%～7%。 將THORplan改用射源y09與SERA搭配射源50c之計算結果作比較。y09射源面積比50c多涵蓋7cm～11cm的半徑範圍，但其超熱中子前向性較差，此二因素影響相消，故改用射源y09對THORplan計算結果影響很小。因此，THORplan與SERA的腫瘤D80點劑量率仍為相差4%，預估照射時間也仍相差4%，正常組織最大劑量相差5%以內。 SERA程式功能限制包括不能使用有外加病人匯聚之治療狀況，計數大小亦有限制，相較於THORplan用於臨床治療有其不便性。
並列摘要
Under the collaboration between National Tsing Hua University(NTHU) and Taipei Veterans General Hospital(TVGH), clinical trial of recurrent head-and-neck cancer by Boron Neutron Capture Therapy(BNCT) started in 2010. Until now 20 patients have been treated. This study is focused on the difference of calculation results between the in-house treatment planning system THORplan and SERA used in Japan and Finland. The source used in THORplan for clinical trial, y09, has space-dependent angular distribution. SERA, however, can not read in source with space-dependent at angular distribution. Therefore, THORplan and SERA were first compared by using Source 50c, a non space-dependent angular dependent neutron source. The results showed that compared with the SERA result, the dose rate calculated by THORplan at Tumor D80 location was higher by 4%, and the normal tissue maximum dose rate were lower by 3%. The estimated irradiation time was shorter by 4%, therefore the normal tissue maximum dose were lower by 5%～7%. When Source 50c was replaced by Source y09 in THORplan calculation, no significant difference was found. The difference of estimated irradiation time between THORplan and SERA remained within 4% and the normal tissue maximum dose were within 5%. Compared with THORplan, the major disadvantage of SERA is unable to simulate the treatment planning condition using patient collimator.
並列關鍵字
無資料參考文獻
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延伸閱讀
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