Hemodialysis is a convenient and main treatment modality for ESRD patients in Taiwan. However, it may also be life-threatening due to massive exposure between the patient's blood and foreign materials. In order to provide hemodialysis patients with a safe environment, dialysis nurses must familiarize themselves with the principles and techniques of nursing care for hemodialysis patients, playing an important role in every dialysis session. In this article, we describe the preparation phase for the dialysis procedure, exploring the pre-dialysis care details, and propose potential protocols for technical preparation before dialysis initiation, in order to deliver a safe hemodialysis session with high quality.