Qualitative and Quantitative Determination of Vanilmandelic Acid (VMA) in Urine

尿中VMA之定性和定量測定

林凱信(Kai-Hsin Lin) ； 陳森輝(Shen-Hui Chen) ； 李廷堅(Ting-Chien Lee)

《Acta Paediatrica Sinica》 21卷2期 (1980/06) Pp. 63-73

摘要

尿中VMA之排泄量分別以Pisano方法和LaBrosse方法來定量和定性測定，以69例正常中國兒童、19例神經母細胞瘤病童、以及16例其它疾病之病童為對象，正常兒童每日尿中VMA排泄量：1歲以下平均為1.7毫克，1至5歲平均為2.3毫克，5至10歲平均為3.0毫克，10至15歲平均為2.9毫克。每日VMA尿中排泄量從出生到5歲之間有漸增之現象。於19例神經母胞瘤病童中，15例每日尿中VMA排泄量遠超出正常兒童排泄量。至於其它疾病之16例，只有l例肝癌的病童其每日尿中VMA排泄量為6毫克以外，其它的都在正常範圍以內。LaBrosse點狀試驗之價值在於操作簡單，節省時間，而可以幫助確定神經母細胞瘤的診斷。LaBrosse點狀試驗的結果和尿中VMA的濃度有正性相關，假陽性反應必須要小心地利用定量的方法來證實。

並列摘要

Urinary vanilmandelic acid (VMA) was measured in 69 normal Chinese children, 19 patients of neuroblastoma, and 16 Patients of other diseases, quantitatively by modified Pisano method and qualitatively by LaBrosse spot test. Mean values of daily VMA excretion in different age groups were 1.7 mg below 1 year of age, 2.3 mg for 1-5 years of age, 3.0 mg for 5-10 years of age, and 2.9 mg for 10-15 years of age. There was an increment of VMA excretion from birth to 5 years of age. Among 19 patients of neurollastoma, 15 patients had much higher values of VMA excretion than that of normal children. VMA excretion of 16 patients with various diseases other than neuroblastoma was all within the normal limits except for one patient with hepatoma, whose VMA excretion was 6 mg/day. LaBrosse spot test was timesaving and simple for confirming the diagnosis of neuroblastoma. The result of LaBrosse spot test correlated well with VMA concentration in urine. False Positive reaction should be ruled out carefully by experienced Personnel and by reproducible quantitative method.

並列關鍵字

vanilmandelic acid (VMA) ； neuroblastoma