Serial Levels of Serum Immunoglobulins in Children with Nephrotic Syndrome

小兒腎變性綜合症的血清免疫球蛋白系列值

黃宜中(Yi-Chung Huang) ； 李標柏(Piao-Po Lee)

《Acta Paediatrica Sinica》 21卷4期 (1980/12) Pp. 264-269

摘要

In order to understand the role of immunological factors in the pat ho genesis of nephrotic syndrome (NS), serum immunoglobulin concentrations were measured serially in 41 children with this syndrome and the results were compared with those found in normal Chinese children. Serum IgG levels, averaging 37% of mean for the age, were significantly reduced in nephrotic patients (P＜0.01). Values for serum IgG were increased after treatment with the alternate-day prednisolone regimen, but the mean values still remained significantly low. Serum IgM concentrations in NS averaged more than twice the mean for the age before, during and after successful treatment with steroid. Serum IgA concentrations were not significantly changed before, during and after steroid treatment in nephrotic patients. Altered immune reactivity may be responsible for the development of NS but the detailed mechanism and pathogenesis are not clearly understood.

並列摘要

In order to understand the role of immunological factors in the pat ho genesis of nephrotic syndrome (NS), serum immunoglobulin concentrations were measured serially in 41 children with this syndrome and the results were compared with those found in normal Chinese children. Serum IgG levels, averaging 37% of mean for the age, were significantly reduced in nephrotic patients (P＜0.01). Values for serum IgG were increased after treatment with the alternate-day prednisolone regimen, but the mean values still remained significantly low. Serum IgM concentrations in NS averaged more than twice the mean for the age before, during and after successful treatment with steroid. Serum IgA concentrations were not significantly changed before, during and after steroid treatment in nephrotic patients. Altered immune reactivity may be responsible for the development of NS but the detailed mechanism and pathogenesis are not clearly understood.

並列關鍵字

serum IgG ； IgM ； IgA ； nephrotic syndrome