小兒中樞神經系統感染疾患脊髓液免疫球蛋白之研究

Cerebrospinal Fluid Immunoglobulins in Children with Central Nervous System Infections

陳百薰(Bai-Hsiun Chen) ； 劉文章(Wen-Jang Liu) ； 江季勛(Chi-Hsiun Chiang)

《Acta Paediatrica Sinica》 23卷3期 (1982/09) Pp. 162-169

摘要

During the period of January 1980 to September 1981, cerebrospinal fluid (CSF) immunoglobulins were measured in 92 children, including 20 aseptic meningitis, 19 purulent meningitis, 15 tuberculous meningitis, 8 eosinophilic meningitis and 30 controls. CSF immunoglobulins concentrations were measured by single radial immunodiffusion method, using concentrations were measured by single radial immunodiffusion method, using commercial LC Partigen immuno-plate (Behring, West Germany). The results showed: ⑴the mean levels of CSF IgG, IgA and IgM in control group were 2.38±1.20mg/dl, 0.23±0.83 mg/dl, and 0mg/dl, respectively. ⑵the mean levels of CSF IgG, IgA and IgM were increased in all cases with central nervous system infection. In aseptic meningitis, purulent meningitis, tuberculous meningitis and eosinophilic meningitis, CSF IgG levels were 5.13±5.92 mg/dl, 44.87±91.45 mg/dl, 25.87±30.45 mg/dl, 10.80±6.63 mg/dl, respectively; CSF IgA levels were 0.81±1.22 mg/dl, 1.92±2.44 mg/dl, 2.74±2.63 mg/dl, 1.19±0.21 mg/dl, respectively; CSF IgM levels were 0.51±0.77 mg/dl, 7.23±11.97 mg/dl, 2.49℃±3.02 mg/dl, 3.24±2.68 mg/dl, respectively. ⑶ The mean levels of CSF immunoglobulin G.A and M in purulent meningitis were significantly higher than those of aseptic meningitis (P＜0.005, P＜0.005, P＜0.01). ⑷There was a correlation between CSF protein levels and CSF IgG, IgA and IgM levels in tuberculous meningitis (r=0.84, P＜0.01, r=0.59, P＜0.05; r=0.85, P＜0.01). ⑸There was a correlation between CSF IgG and protein levels in both aseptic meningitis and control group (r=0.67, P＜0.01; r=0.69, P＜0.01). ⑹There was no correlation between CSF IgG and serum IgG levels in aseptic meningitis, purulent meningitis and eosinophilic meningitis (r=0.31, P＞0.05; r=0.35, P＞0.05; r=0.25, P＞0.05).

並列摘要

During the period of January 1980 to September 1981, cerebrospinal fluid (CSF) immunoglobulins were measured in 92 children, including 20 aseptic meningitis, 19 purulent meningitis, 15 tuberculous meningitis, 8 eosinophilic meningitis and 30 controls. CSF immunoglobulins concentrations were measured by single radial immunodiffusion method, using concentrations were measured by single radial immunodiffusion method, using commercial LC Partigen immuno-plate (Behring, West Germany). The results showed: ⑴the mean levels of CSF IgG, IgA and IgM in control group were 2.38±1.20mg/dl, 0.23±0.83 mg/dl, and 0mg/dl, respectively. ⑵the mean levels of CSF IgG, IgA and IgM were increased in all cases with central nervous system infection. In aseptic meningitis, purulent meningitis, tuberculous meningitis and eosinophilic meningitis, CSF IgG levels were 5.13±5.92 mg/dl, 44.87±91.45 mg/dl, 25.87±30.45 mg/dl, 10.80±6.63 mg/dl, respectively; CSF IgA levels were 0.81±1.22 mg/dl, 1.92±2.44 mg/dl, 2.74±2.63 mg/dl, 1.19±0.21 mg/dl, respectively; CSF IgM levels were 0.51±0.77 mg/dl, 7.23±11.97 mg/dl, 2.49℃±3.02 mg/dl, 3.24±2.68 mg/dl, respectively. ⑶ The mean levels of CSF immunoglobulin G.A and M in purulent meningitis were significantly higher than those of aseptic meningitis (P＜0.005, P＜0.005, P＜0.01). ⑷There was a correlation between CSF protein levels and CSF IgG, IgA and IgM levels in tuberculous meningitis (r=0.84, P＜0.01, r=0.59, P＜0.05; r=0.85, P＜0.01). ⑸There was a correlation between CSF IgG and protein levels in both aseptic meningitis and control group (r=0.67, P＜0.01; r=0.69, P＜0.01). ⑹There was no correlation between CSF IgG and serum IgG levels in aseptic meningitis, purulent meningitis and eosinophilic meningitis (r=0.31, P＞0.05; r=0.35, P＞0.05; r=0.25, P＞0.05).

並列關鍵字

central nervous system infection ； cerebrospinal fluid immunoglobulins