Studies of Neuron - Specific Enolase Levels in Serum and Cerebrospinal Fluid of Children with Neurological Diseases

小兒中樞神經性疾患血清及脊髓液中NSE之研究

柯芳蓉(Fang-Jong Ko) ； 江季勛(Chi-Hsiun Chiang) ； 吳莉莉(Lily Wu) ； 吳重慶(Chung-Chih Wu)

《The Kaohsiung Journal of Medical Sciences》 6卷3期 (1990/03) Pp. 137-143

https://doi.org/10.6452/KJMS.199003.0137

摘要

Neuron-specific enolase (NSE) has recently proved to be an useful marker of neuron damage. We determined NSE levels in the serum and SCF of 117 children with various neurological disorders (43 with febrile con-vulsion, 25 with seizure disorder, 32 with meningitis, 3 with brain tumor, 2with Reye syndrome, 3 with congenital CNS malformation and 9 with other disorders). The purpose of this study is to assess the potential usefulness of NSE in diagnosis and prognosis.
Twenty CSF and serum samples of children without neurological problem served as a control. The mean values of the NSE levels in the CSF and serum of the control group were 5.00±1.65 ng/ml and 8.34±4.40 ng/ml respectively. The peak values were found in cases with brain tumor. A patient died of Reye syndrome didn’t show a very high level of NSE in the serum or CSF. However, we found signific differences in NSE levels between the patients with febrile convulsions and those with seizure disorders (non-febrile, abnormal EEG). Most of our patients with febrile convulsions were cases of simple febrile convulsion, and their NSE levesin the CSF and serum were 4.55±1.00 and 8.06±3.18 ng/ml. Cases with non-febrile seizure dis-orders had significantly higher level of NSE in both CSF and serum (P＜0.05). Patients with purulent meningitis usually had higher levels than those with aseptic meningitis.
Our study can be summarized thus: 1. A normal level of NSE does not exclude severe neuron damage. 2. Although it is too early to say whether a febrile convulsion patient with a high level of NSE will develop a case of non-febrile seizure disorder, NSE still has its potential usefulness in assess-ment of the prognosis. 3. it is worth checking the NSE level of patients with meningitis. 4. NSE is a sensitive biochemical marker in patients with brain tumor.

並列摘要

Neuron-specific enolase (NSE) has recently proved to be an useful marker of neuron damage. We determined NSE levels in the serum and SCF of 117 children with various neurological disorders (43 with febrile con-vulsion, 25 with seizure disorder, 32 with meningitis, 3 with brain tumor, 2with Reye syndrome, 3 with congenital CNS malformation and 9 with other disorders). The purpose of this study is to assess the potential usefulness of NSE in diagnosis and prognosis.
Twenty CSF and serum samples of children without neurological problem served as a control. The mean values of the NSE levels in the CSF and serum of the control group were 5.00±1.65 ng/ml and 8.34±4.40 ng/ml respectively. The peak values were found in cases with brain tumor. A patient died of Reye syndrome didn’t show a very high level of NSE in the serum or CSF. However, we found signific differences in NSE levels between the patients with febrile convulsions and those with seizure disorders (non-febrile, abnormal EEG). Most of our patients with febrile convulsions were cases of simple febrile convulsion, and their NSE levesin the CSF and serum were 4.55±1.00 and 8.06±3.18 ng/ml. Cases with non-febrile seizure dis-orders had significantly higher level of NSE in both CSF and serum (P＜0.05). Patients with purulent meningitis usually had higher levels than those with aseptic meningitis.
Our study can be summarized thus: 1. A normal level of NSE does not exclude severe neuron damage. 2. Although it is too early to say whether a febrile convulsion patient with a high level of NSE will develop a case of non-febrile seizure disorder, NSE still has its potential usefulness in assess-ment of the prognosis. 3. it is worth checking the NSE level of patients with meningitis. 4. NSE is a sensitive biochemical marker in patients with brain tumor.

並列關鍵字

Neuron-specific Enolase (NSE) ； Neurological disorders