Cerebrospinal Fluid Interleukin-6, Interleukin-8, and Tumor Necrosis Factor-α in Children with Central Nervous System Infections

兒童中樞神經系統感染腦脊髓液Interleukin-6，Interleukin-8和Tumor Necrosis factor-α之濃度

蔡明蘭(Min-Lan Tsai) ； 陳五常(Wu-Charng Chen) ； 王允中(Yun-Chung Wang) ； 洪焜隆(Kun-Long Hung)

《Acta Paediatrica Sinica》 37卷1期 (1996/02) Pp. 16-21

https://doi.org/10.7097/APS.199602.0016

摘要

Concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in cerebrospinal (CSF) samples were determined from 11 control and 42 children with central nervous system infections including 11 patients with bacterial meningitis, 20 patients with aseptic meningitis, 11 patients with encephalitis. The CSF IL-6, IL-8 and TNF-α concentrations in patients with bacterial meningitis were significantly higher than those with aseptic meningitis, encephalitis and the control groups. CSF IL-6, IL-8 and TNF-α levels in patients with aseptic meningitis were also significantly higher than those in the control group. There was no significant increase of CSF IL-6, IL-8 and TNF-αconcentrations in patients with encephalitis compared to the control group. CSF IL-6 and TNF-αconcentrations were decreased in patients with bacterial meningitis after treatment. CSF IL-8 levels were significantly decreased in both bacterial and aseptic meningitis groups at recovery period. There were no correlation between CSF IL-6, IL-8 and TNF-αlevels and other parameters including CSF leukocytes, protein, sugar, IgG levels and IgG indexes in patients with bacterial meningitis. These results suggest that IL-6, IL-8 and TNF-a are important mediators in the meningeal inflammatory process in patients with meningitis. The levels of these mediators are good indicators for the extent of the meningeal inflammation

關鍵字

interleukin-6 ； interleukin-8 ； tumor necrosis factor-α ； 細菌性腦膜炎 ； 無菌性腦膜炎 ； 腦炎 ； 腦脊髓液

並列摘要

Concentrations of interleukin-6 (IL-6), interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α) in cerebrospinal (CSF) samples were determined from 11 control and 42 children with central nervous system infections including 11 patients with bacterial meningitis, 20 patients with aseptic meningitis, 11 patients with encephalitis. The CSF IL-6, IL-8 and TNF-α concentrations in patients with bacterial meningitis were significantly higher than those with aseptic meningitis, encephalitis and the control groups. CSF IL-6, IL-8 and TNF-α levels in patients with aseptic meningitis were also significantly higher than those in the control group. There was no significant increase of CSF IL-6, IL-8 and TNF-αconcentrations in patients with encephalitis compared to the control group. CSF IL-6 and TNF-αconcentrations were decreased in patients with bacterial meningitis after treatment. CSF IL-8 levels were significantly decreased in both bacterial and aseptic meningitis groups at recovery period. There were no correlation between CSF IL-6, IL-8 and TNF-αlevels and other parameters including CSF leukocytes, protein, sugar, IgG levels and IgG indexes in patients with bacterial meningitis. These results suggest that IL-6, IL-8 and TNF-a are important mediators in the meningeal inflammatory process in patients with meningitis. The levels of these mediators are good indicators for the extent of the meningeal inflammation

並列關鍵字

interleukin-6 (IL-6) ； interleukin-8 (IL-8) ； Tumor necrosis factor-α(TNF-α) ； bacterial meningitis ； aseptic meningitis ； encephalitis ； cerebrospinal fluid (CSF)