正常兒童及具左至右分流先天性心臓病病童於高濃度氧氣下肺血管阻力變化之研究

Study of Pulmonary Vascular Resistance Changes During Breathing of a High Concentration Oxygen by Normal Children and Children with Congenital Heart Disease and Left-to-Right Shunts

黃金萬(Chin-Wang Hwang) ； 張嘉侃(Jia-Kan Chang) ； 趙治中(Chih-Chung Chao) ； 陳維廉(Wei-Lian Chen) ； 張福庚(Fu-Ken Chang) ； 吳玉村(Yuh-Tsuen Wu)

《Acta Paediatrica Sinica》 26卷3期 (1985/06) Pp. 243-248

摘要

Twenty-five children were assessed by cardiac catheterization and first-pass nuclear angiocardiography (FPNA), first while breathing ordinary room air and then after breathing high concentration oxygen for 20 minutes. Among the 25 cases, group one included 8 children without left-to-right shunt; group two, 9 cases who had left-to-right shunts without pulmonary hypertension; group three consisted of 8 cases with left-to-right shunts and pulmonary hypertension. The total pulmonary resistance to total systemic resistance ratio (TPR/TSR) and pulmonary arteriolar resistance to total systemic resistance ratio (PAR/TSR) were calculated. No significant changes were found in groups one and two (P＞0.05), but there was a significant change in group three (P＜0.O1). Decreasing rates of TPR/TSR and PAR/TSR were measured after the patients breathed a high concentration of oxygen. There was no significant difference between groups one and two (P＞0.05), but there was a significant difference between group one aid three (P0.01). Calculation by FPNA of the increased rate of pulmonary blood flow to systemic blood flow after breathing a high concentration of oxygen showed significant differences between group one compared with group two and three (P＜0.01).

並列摘要

Twenty-five children were assessed by cardiac catheterization and first-pass nuclear angiocardiography (FPNA), first while breathing ordinary room air and then after breathing high concentration oxygen for 20 minutes. Among the 25 cases, group one included 8 children without left-to-right shunt; group two, 9 cases who had left-to-right shunts without pulmonary hypertension; group three consisted of 8 cases with left-to-right shunts and pulmonary hypertension. The total pulmonary resistance to total systemic resistance ratio (TPR/TSR) and pulmonary arteriolar resistance to total systemic resistance ratio (PAR/TSR) were calculated. No significant changes were found in groups one and two (P＞0.05), but there was a significant change in group three (P＜0.O1). Decreasing rates of TPR/TSR and PAR/TSR were measured after the patients breathed a high concentration of oxygen. There was no significant difference between groups one and two (P＞0.05), but there was a significant difference between group one aid three (P0.01). Calculation by FPNA of the increased rate of pulmonary blood flow to systemic blood flow after breathing a high concentration of oxygen showed significant differences between group one compared with group two and three (P＜0.01).

並列關鍵字

pulmonary resistance ； systemic resistance ； pulmonary blood flow ； systemic blood flow ； pulmonary hypertemsion