Clinical Observation of Neonatal Septicemia

新生兒敗血症臨床觀察

魏穀年(Ku-Nein Wei) ； 黃富源(Fu-Yuan Huang) ； 李燕晉(Yen-Chin Lee) ； 吳建志(Chen-Chue Wu)

《Acta Paediatrica Sinica》 27卷5期 (1986/10) Pp. 409-418

摘要

From January 1981 to June 1983, 160 cases of neonatal septicemia with positive blood cultures were collected at Mackay Memorial Hospital. Male to female ratio was 1.8:1 (P＜0.001). Of the 160 cases, 48 cases (30.0%) belonged to the early onset septicemia (those occurring within the first 72 hours of life) and 112 cases (73.0%) belonged to the late onset group (those occurring beyond 72 hours old). The Gram negative organisms comprised 120 isolates and the Gram positive organisms, 45 isolates. The most common causative agent was E. coli (19.5%), followed by Pseudomonas aeruginosa (15.8%), Staphylococcus aureus (14.6%), Klebsiella pneumoniae (11.0%) and Streptococcus (6.7%). The incidence of group B (l-hemolytic streptococcus was 2.4% only. Among the Gram positive cocci, 89.6% were sensitive to oxacillin, 82.2% to cephalothin. 39.6% to ampicillin and 37.5% to penicillin. Among the gram negative bacilli, 92.8% were sensitive to piperacillin, 76.6% were sensitive to gentamicin, 73.0% to amikacin and 36.7% to carbenicillin. The clinical symptoms and signs were non-specific. Forty-five cases had predisposing factor(s), among which prematurity was the most common. The overall mortality rate was 26.25%. The mortality rate was statistically different between the early onset and late onset group, the Gram negative and Gram Positive septicemias and those with and without predisposing factors.

並列摘要

From January 1981 to June 1983, 160 cases of neonatal septicemia with positive blood cultures were collected at Mackay Memorial Hospital. Male to female ratio was 1.8:1 (P＜0.001). Of the 160 cases, 48 cases (30.0%) belonged to the early onset septicemia (those occurring within the first 72 hours of life) and 112 cases (73.0%) belonged to the late onset group (those occurring beyond 72 hours old). The Gram negative organisms comprised 120 isolates and the Gram positive organisms, 45 isolates. The most common causative agent was E. coli (19.5%), followed by Pseudomonas aeruginosa (15.8%), Staphylococcus aureus (14.6%), Klebsiella pneumoniae (11.0%) and Streptococcus (6.7%). The incidence of group B (l-hemolytic streptococcus was 2.4% only. Among the Gram positive cocci, 89.6% were sensitive to oxacillin, 82.2% to cephalothin. 39.6% to ampicillin and 37.5% to penicillin. Among the gram negative bacilli, 92.8% were sensitive to piperacillin, 76.6% were sensitive to gentamicin, 73.0% to amikacin and 36.7% to carbenicillin. The clinical symptoms and signs were non-specific. Forty-five cases had predisposing factor(s), among which prematurity was the most common. The overall mortality rate was 26.25%. The mortality rate was statistically different between the early onset and late onset group, the Gram negative and Gram Positive septicemias and those with and without predisposing factors.

並列關鍵字

neonatal septicemia ； antibiotics sensitvity ； predisposing factor ； mortality rate