並列摘要
The role of the vagus in bronchial asthma implicates to suggest that parasympatholytics are potent drugs in asthma therapy. The most important parasympatholytics today are ipratropium and oxitropium bromide. They are effective by blocking the cholinergic or muscarinic receptors of the bronchial smooth muscle and thereby inhibit cholinergic bronchomotor tone. Although they are generally somewhat less effective bronchodilators compared to β2-adrenergics, they are potent antiasthmatic drugs especially in infants and small children, in whom β2-adrenergics seem to be not so much effective. As with inhaled β2-adrenergics a correct inhalation technique is required for an optimal effect with parasympatholytics as well, but it could be shown that both groups of substances do have a good antiobstructive effect even when just sprayed into the mouth. Apart from the theoretical implications discussed the clinical importance of these findings for the antiobstructive treatment of those patients unable to inhale properly including infants and small children is emphasized.
延伸閱讀
- 楊笑嵐、吳仁達（2006）。精神異常治療藥的藥理與合成。化學，64(2)，217-223。https://doi.org/10.6623/chem.2006015
- 林秀娥（1994）。交感神經α1-接受體阻斷劑 dicentrine 衍生物之合成研究〔碩士論文，臺北醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0007-1704200714352779
- 莊綉雯、李欣南（2003）。精神科藥物用為輔助性止痛劑。台灣醫學，7(5)，797-803。https://doi.org/10.6320/FJM.2003.7(5).17
- 謝明憲、林信男（2002）。長效型抗精神病藥之使用。當代醫學，(350)，997-1001。https://doi.org/10.29941/MT.200212.0011
- 張天鈞（2009）。體抑素作用類似物治療神經內分泌腫瘤所扮演的角色。當代醫學，(430)，609-613。https://doi.org/10.29941/MT.200908.0010