Insulin-Like Growth Factor-I in Prednisolone-Treated Children

接受prednisolone治療兒童的類胰島素生長第一因子(IGF-I)之研究

曹永魁(Yong-Kwei Tsau) ； 李俊賢(Jing-Sheng Lee) ； 陳烱暉(Chiung-Huei Chen)

《Acta Paediatrica Sinica》 31卷1期 (1990/02) Pp. 11-16

摘要

Impaired linear growth is a well-known side effect of long-term steroid therapy in children. To assess the steroid effects on plasma insulin-like growth factor 1 (IGF-I), 11 children with prednisolone treatment were evaluated for longitudinal study of IGF-l changes. The mean plasma IGF-I level without prednisolone use was 1.39±1.03 u/ml, while that on prednisolone therapy for a minimum of 10 days was 2.95±1.16 u/ml. A significant increase in plasma IGF-I concentrations was noted during long-term (more than 10 days) prednisolone therapy (P＜0.001), but not found shortly after prednisolone administration. Our findings suggest that growth suppression of the steroid is not due to impaired IGF-I production, but rather, due to a defective IGF-I action either by end-organ unresponsiveness or via somatomedin inhibitors.

並列摘要

Impaired linear growth is a well-known side effect of long-term steroid therapy in children. To assess the steroid effects on plasma insulin-like growth factor 1 (IGF-I), 11 children with prednisolone treatment were evaluated for longitudinal study of IGF-l changes. The mean plasma IGF-I level without prednisolone use was 1.39±1.03 u/ml, while that on prednisolone therapy for a minimum of 10 days was 2.95±1.16 u/ml. A significant increase in plasma IGF-I concentrations was noted during long-term (more than 10 days) prednisolone therapy (P＜0.001), but not found shortly after prednisolone administration. Our findings suggest that growth suppression of the steroid is not due to impaired IGF-I production, but rather, due to a defective IGF-I action either by end-organ unresponsiveness or via somatomedin inhibitors.

並列關鍵字

somatomedin-C ； insulin-like growth factor I ； prednisolone therapy