Chemotherapy-Related Side Effects in Children with Acute Lymphocytic Leukemia in Taiwan: A Nursing Perspective

本研究的目的在於探討急性淋巴性白血病兒童接受TPOG-882化學治療方案時在誘導期及鞏固期副作用之發生型態，以作爲護理人員照護病童時護理活動之根據。研究對象爲在台灣18個治療中心接受治療之病童101位。資料收集為期一年。由病童之主護護士負責檢查資料並將所觀察到的副作用逐日記錄，再根據所得資料加以整理分析。101位個案中，去除死亡及其他因素流失22位，共得有效資料79份，其中包括一般危險組(SR)52份、高危險組(HR)27份。分析結果顯示I)SR組感染率為19%，HR組22%。Ⅱ)化學治療誘發之副作用主要為⑴體溫升高，⑵胃口差，惡心、嘔吐，⑶口腔黏膜破損，⑷肛門黏膜破損，⑸腹瀉，⑹活動力受影響。Ⅲ)化學治療之低谷期爲前三週，白血球計數降至最低，副作用升至最高。根據所得資料，護理活動宜包括⑴預防感染，⑵减輕症狀，⑶維持舒適，及⑷熟練的觀察技巧與心理支持。

關鍵字

無資料

並列摘要

The purpose of this study was to understand the pattern of side effects experienced by children with acute lymphocytic leukemia (ALL) who were receiving the induction and consolidation phases of a specific chemotherapy regimen. One hundred and one children with ALL in treatment centers throughout Taiwan in June 1990 through June 1991 served as the sample for this study. Children had been divided into two groups, a standard risk group (SR) and a high risk group (HR), which received different therapeutic regimens. Of 101 children, 52 in SR and 27 in HR completed the induction and consolidation phases of treatment. Among sources of data for the study were nurses' prospective close observations in the natural care setting of each child. Chemotherapy-related side effects are multifaceted and intrusive, including changes in hematopoietic function, body function and body appearance. The most common side effects with regard to body function were elevation of body temperature, ulceration of oral mucous membrane, poor appetite, nausea and vomiting, ulceration of anus, diarrhea, impaired mobility. Side effects were greatest during the first through third weeks of the chemotherapy regimen. Twenty percent of the children developed infection. The findings stressed that nurses should be aware of such patterns of side effects so that they can provide optimal care to patients receiving chemotherapy.

並列關鍵字

children with acute lymphocytic leukemia ； chemotherapy-related side effects ； nursing care

國際替代計量

未授權

主題瀏覽