- 期刊
Neonatal Meningococcal Meningitis: Report of Two Cases
新生兒腦膜炎雙球菌腦膜炎：二病例報告
摘要
由腦膜炎雙球菌(Neisseria meningitidis)引起的新兒腦膜炎並不常見，在抗生素發展的年代，迄今只有個22病例曾在英文文獻中被報告過，在這此病例中，至少有7例存活而沒有任何後遺症，其中已知有6例接受了7到14天不等的penicillin治療。 本篇報告二新生兒腦膜 炎雙球菌腦膜炎的病例，此二病例是28天大男嬰及16天大女嬰，他們皆因發燒、喂食及活動力不佳而入院，二者在血液及腦脊髓液都培養出腦膜炎雙球菌，並在分別接受22天及15天的抗生素治療之後，二者均疥瘡而無後遺症。 查閱前人的報告得知，新生兒腦膜炎雙球菌腦膜炎的死亡率很高，但若能早期診斷並接受有效而足夠的治療，亦能疥瘡而無後遺症，對此病而言，似乎14天的治療應屬足夠，雖然在文獻中有少數用較短期間的抗生素而治療成功的例子，但是病例數不多，需等將來累積更多的經驗才能做最後的結論。
並列摘要
Two neonates with meningococcal meningitis and meningococcemia are reported. The two, aged 28 and 16 days, respectively, presented similar symptoms of fever, poor appetite and poor activity. Both blood and cerebrospinal fluid cultures of each patient grew Neisseria meningitidis. The isolated bacteria were sensitive to penicillin, and both patients recovered completely after penicillin treatment for 22 and 15 days, respectively. In the antibiotic era, only 22 cases of neonatal meningococcal meningitis have been reported in the English literature. Among these reports, at least 7 patients survived without sequelae; 6 of those were treated with different combinations of antibiotics, including penicillin, for variable durations of 7-14 days. Therefore, effective antibiotic therapy for 14 days should be adequate in the treatment of uncomplicated neonatal meningococcal meningitis and meningococcemia.
延伸閱讀
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